UniProt Accession

 SEC13_HUMAN; P55735; A8MV37; Q5BJF0; Q9BRM6; Q9BUG7 

Genbank Protein ID

 L09260; AF052155; AC022384; BC002634; BC006167; BC091506 

Genbank Nucleotide ID

 AAH02634.2; AAH06167.1; AAH91506.1 

Protein Name

 Protein SEC13 homolog 

Protein Synonyms/Alias

 SEC13-like protein 1; SEC13-related protein 

Gene Name

 SEC13 

Gene Synonyms/Alias

 D3S1231E; SEC13L1; SEC13R 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
38	CSSDRSVKIFDVRNG	ubiquitination	[1, 2]
175	IDHPSGQKPNYIKRF	ubiquitination	[1, 2]
180	GQKPNYIKRFASGGC	ubiquitination	[2]
192	GGCDNLIKLWKEEED	ubiquitination	[2]
256	SSNTWSPKLLHKFND	ubiquitination	[1, 2]
260	WSPKLLHKFNDVVWH	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. 

Sequence Annotation

 REPEAT 11 50 WD 1.
 REPEAT 55 96 WD 2.
 REPEAT 101 144 WD 3.
 REPEAT 148 204 WD 4.
 REPEAT 210 253 WD 5.
 REPEAT 260 299 WD 6.
 MOD_RES 2 2 N-acetylvaline.
 MOD_RES 309 309 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Endoplasmic reticulum; ER-Golgi transport; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Repeat; Translocation; Transport; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 322 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome.
 GO:0031080; C:nuclear pore outer ring; IDA:UniProtKB.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome.
 GO:0048208; P:COPII vesicle coating; TAS:Reactome.
 GO:0006886; P:intracellular protein transport; NAS:UniProtKB.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0043687; P:post-translational protein modification; TAS:Reactome.
 GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome. 

Interpro

 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS