CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016955
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Palmitoyltransferase ZDHHC13 
Protein Synonyms/Alias
 Huntingtin-interacting protein 14-related protein; HIP14-related protein; Huntingtin-interacting protein HIP3RP; Putative MAPK-activating protein PM03; Putative NF-kappa-B-activating protein 209; Zinc finger DHHC domain-containing protein 13; DHHC-13 
Gene Name
 ZDHHC13 
Gene Synonyms/Alias
 HIP14L; HIP3RP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
38PSLNVVDKIHQNTPLubiquitination[1]
73SLDIQNVKGETPLDMubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
 Palmitoyltransferase for HD and GAD2 (By similarity). Mediates Mg(2+) transport (By similarity). 
Sequence Annotation
 REPEAT 81 110 ANK 1.
 REPEAT 115 144 ANK 2.
 REPEAT 148 177 ANK 3.
 REPEAT 181 211 ANK 4.
 REPEAT 216 245 ANK 5.
 REPEAT 249 277 ANK 6.
 ZN_FING 426 476 DHHC-type.
 ACT_SITE 456 456 S-palmitoyl cysteine intermediate (By  
Keyword
 Acyltransferase; Alternative splicing; ANK repeat; Complete proteome; Cytoplasmic vesicle; Golgi apparatus; Ion transport; Lipoprotein; Magnesium; Membrane; Metal-binding; Palmitate; Polymorphism; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Transport; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 622 AA 
Protein Sequence
MTDVNGQTPL MLSAHKVIGP EPTGFLLKFN PSLNVVDKIH QNTPLHWAVA AGNVNAVDKL 60
LEAGSSLDIQ NVKGETPLDM ALQNKNQLII HMLKTEAKMR ANQKFRLWRW LQKCELFLLL 120
MLSVITMWAI GYILDFNSDS WLLKGCLLVT LFFLTSLFPR FLVGYKNLVY LPTAFLLSSV 180
FWIFMTWFIL FFPDLAGAPF YFSFIFSIVA FLYFFYKTWA TDPGFTKASE EEKKVNIITL 240
AETGSLDFRT FCTSCLIRKP LRSLHCHVCN CCVARYDQHC LWTGRCIGFG NHHYYIFFLF 300
FLSMVCGWII YGSFIYLSSH CATTFKEDGL WTYLNQIVAC SPWVLYILML ATFHFSWSTF 360
LLLNQLFQIA FLGLTSHERI SLQKQSKHMK QTLSLRKTPY NLGFMQNLAD FFQCGCFGLV 420
KPCVVDWTSQ YTMVFHPARE KVLRSV 446 
Gene Ontology
 GO:0030660; C:Golgi-associated vesicle membrane; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0015095; F:magnesium ion transmembrane transporter activity; ISS:UniProtKB.
 GO:0016409; F:palmitoyltransferase activity; ISS:UniProtKB.
 GO:0004871; F:signal transducer activity; IMP:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR001594; Znf_DHHC_palmitoyltrfase. 
Pfam
 PF12796; Ank_2
 PF01529; zf-DHHC 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50216; ZF_DHHC 
PRINTS