CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019222
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Microspherule protein 1 
Protein Synonyms/Alias
 58 kDa microspherule protein; Cell cycle-regulated factor p78; INO80 complex subunit J; MCRS2 
Gene Name
 MCRS1 
Gene Synonyms/Alias
 INO80Q; MSP58 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
123TKRVKKSKQPLQVTKacetylation[1]
130KQPLQVTKDLGRWKPacetylation[1]
211QSKALFSKAEEQLLSubiquitination[2]
219AEEQLLSKVGSTSQPubiquitination[2]
458LIRAEAAKITPQ***ubiquitination[2]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. 
Sequence Annotation
 DOMAIN 363 419 FHA.
 MOTIF 113 123 Nuclear localization signal (Potential).
 MOD_RES 22 22 Phosphoserine.
 MOD_RES 103 103 Phosphothreonine.
 MOD_RES 108 108 Phosphoserine.
 MOD_RES 123 123 N6-acetyllysine.
 MOD_RES 130 130 N6-acetyllysine.
 MOD_RES 282 282 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Chromatin regulator; Coiled coil; Complete proteome; DNA damage; DNA recombination; DNA repair; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 462 AA 
Protein Sequence
MDKDSQGLLD SSLMASGTAS RSEDEESLAG QKRASSQALG TIPKRRSSSR FIKRKKFDDE 60
LVESSLAKSS TRAKGASGVE PGRCSGSEPS SSEKKKVSKA PSTPVPPSPA PAPGLTKRVK 120
KSKQPLQVTK DLGRWKPADD LLLINAVLQT NDLTSVHLGV KFSCRFTLRE VQERWYALLY 180
DPVISKLACQ AMRQLHPEAI AAIQSKALFS KAEEQLLSKV GSTSQPTLET FQDLLHRHPD 240
AFYLARTAKA LQAHWQLMKQ YYLLEDQTVQ PLPKGDQVLN FSDAEDLIDD SKLKDMRDEV 300
LEHELMVADR RQKREIRQLE QELHKWQVLV DSITGMSSPD FDNQTLAVLR GRMVRYLMRS 360
REITLGRATK DNQIDVDLSL EGPAWKISRK QGVIKLKNNG DFFIANEGRR PIYIDGRPVL 420
CGSKWRLSNN SVVEIASLRF VFLINQDLIA LIRAEAAKIT PQ 462 
Gene Ontology
 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0000123; C:histone acetyltransferase complex; IDA:UniProtKB.
 GO:0031011; C:Ino80 complex; IDA:UniProtKB.
 GO:0071339; C:MLL1 complex; IDA:UniProtKB.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0043984; P:histone H4-K16 acetylation; IDA:UniProtKB.
 GO:0043981; P:histone H4-K5 acetylation; IDA:UniProtKB.
 GO:0043982; P:histone H4-K8 acetylation; IDA:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000253; FHA_dom.
 IPR025999; MCRS_N.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF00498; FHA
 PF13325; MCRS_N 
SMART
 SM00240; FHA 
PROSITE
 PS50006; FHA_DOMAIN 
PRINTS