UniProt Accession

 A8MY43_HUMAN; A8MY43 

Genbank Protein ID

 AC135050; CH471192 

Genbank Nucleotide ID

 EAW52163.1 

Protein Name

 Branched chain ketoacid dehydrogenase kinase, isoform CRA_c 

Protein Synonyms/Alias

 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 

Gene Name

 BCKDK 

Gene Synonyms/Alias

 hCG_21145 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
48	EMARERSKTVTSFYN	ubiquitination	[1]
192	LVRYFLDKTLTSRLG	acetylation	[2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Kinase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 365 AA 

Protein Sequence

Gene Ontology

 GO:0005947; C:mitochondrial alpha-ketoglutarate dehydrogenase complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:Compara. 

Interpro

 IPR018955; BCDHK/PDK_N.
 IPR003594; HATPase_ATP-bd. 

Pfam

 PF10436; BCDHK_Adom3
 PF02518; HATPase_c 

SMART

 SM00387; HATPase_c 

PROSITE

  

PRINTS