CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031645
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pdk3 protein 
Protein Synonyms/Alias
 Protein Pdk3; Pyruvate dehydrogenase kinase, isoenzyme 3 (Mapped), isoform CRA_a 
Gene Name
 Pdk3 
Gene Synonyms/Alias
 Pdk3_mapped; rCG_36457 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
134AQGVIEYKEKFGFDPacetylation[1]
264VELYEDKKEGYPAVKacetylation[1]
278KTLVTLGKEDLSIKIacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Pyruvate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 415 AA 
Protein Sequence
MRLFYRLLKQ PVPKQIERYS RFSPSPLSIK QFLDFGRDNA CEKTSYMFLR KELPVRLANT 60
MREVNLLPDN LLNRPSVGLV QSWYMQSFLE LLEYENKSPE DPRVLDNFLH VLINIRNRHN 120
DVVPTMAQGV IEYKEKFGFD PFISSNIQYF LDRFYTNRIS FRMLINQHTL LFGGDTNPAH 180
PKHIGSIDPT CNVADVVKDA YETAKMLCEQ YYLVAPELEV EEFNAKAPNK PIQVVYVPSH 240
LFHMLFELFK NSMRATVELY EDKKEGYPAV KTLVTLGKED LSIKISDLGG GVPLRKIDRL 300
FNYMYSTAPR PSLEPTRAAP LAGFGYGLPI SRLYARYFQG DLKLYSMEGV GTDAVIYLKA 360
LSSESFERLP VFNKSAWRHY KTTPEADDWS NPSSEPRDAS KYKAKQDKIK SNKTF 415 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:Compara.
 GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; IEA:Compara.
 GO:0071398; P:cellular response to fatty acid; IEA:Compara.
 GO:0071333; P:cellular response to glucose stimulus; IMP:UniProtKB.
 GO:0097411; P:hypoxia-inducible factor-1alpha signaling pathway; IEA:Compara.
 GO:0018105; P:peptidyl-serine phosphorylation; IEA:Compara.
 GO:0035357; P:peroxisome proliferator activated receptor signaling pathway; IEA:Compara.
 GO:0010510; P:regulation of acetyl-CoA biosynthetic process from pyruvate; IEA:Compara.
 GO:0010906; P:regulation of glucose metabolic process; IEA:Compara.
 GO:2000377; P:regulation of reactive oxygen species metabolic process; IEA:Compara. 
Interpro
 IPR018955; BCDHK/PDK_N.
 IPR003594; HATPase_ATP-bd.
 IPR005467; Sig_transdc_His_kinase_core. 
Pfam
 PF10436; BCDHK_Adom3
 PF02518; HATPase_c 
SMART
 SM00387; HATPase_c 
PROSITE
 PS50109; HIS_KIN 
PRINTS