CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000239
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Suppressor of cytokine signaling 3 
Protein Synonyms/Alias
 SOCS-3; Cytokine-inducible SH2 protein 3; CIS-3; STAT-induced STAT inhibitor 3; SSI-3 
Gene Name
 SOCS3 
Gene Synonyms/Alias
 CIS3; SSI3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
28RLKTFSSKSEYQLVVubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). 
Sequence Annotation
 DOMAIN 46 142 SH2.
 DOMAIN 177 224 SOCS box.
 REGION 22 33 Kinase inhibitory region (KIR).
 REGION 34 45 Extended SH2 subdomain (ESS).  
Keyword
 Complete proteome; Growth regulation; Pharmaceutical; Phosphoprotein; Polymorphism; Reference proteome; SH2 domain; Signal transduction inhibitor; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 225 AA 
Protein Sequence
MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL 60
SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV 120
LKLVHHYMPP PGAPSFPSPP TEPSSEVPEQ PSAQPLPGSP PRRAYYIYSG GEKIPLVLSR 180
PLSSNVATLQ HLCRKTVNGH LDSYEKVTQL PGPIREFLDQ YDAPL 225 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004860; F:protein kinase inhibitor activity; TAS:ProtInc.
 GO:0060670; P:branching involved in labyrinthine layer morphogenesis; IEA:Compara.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; TAS:Reactome.
 GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc.
 GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Compara.
 GO:0060674; P:placenta blood vessel development; IEA:Compara.
 GO:0045597; P:positive regulation of cell differentiation; IEA:Compara.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
 GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0060338; P:regulation of type I interferon-mediated signaling pathway; TAS:Reactome.
 GO:0060708; P:spongiotrophoblast differentiation; IEA:Compara.
 GO:0060707; P:trophoblast giant cell differentiation; IEA:Compara.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. 
Interpro
 IPR000980; SH2.
 IPR001496; SOCS_C. 
Pfam
 PF00017; SH2
 PF07525; SOCS_box 
SMART
 SM00252; SH2
 SM00253; SOCS
 SM00969; SOCS_box 
PROSITE
 PS50001; SH2
 PS50225; SOCS 
PRINTS