CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025876
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2, isoform CRA_b 
Protein Synonyms/Alias
 MKIAA4195 protein 
Gene Name
 Atp2a2 
Gene Synonyms/Alias
 mKIAA4195; mCG_12168 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
145EYEPEMGKVYRQDRKubiquitination[1]
160SVQRIKAKDIVPGDIubiquitination[1]
175VEIAVGDKVPADIRLubiquitination[1]
186DIRLTSIKSTTLRVDubiquitination[1]
477NVFDTELKGLSKIERubiquitination[1]
493NACNSVIKQLMKKEFubiquitination[1]
509LEFSRDRKSMSVYCTubiquitination[1]
519SVYCTPNKPSRTSMSubiquitination[1]
527PSRTSMSKMFVKGAPubiquitination[1]
531SMSKMFVKGAPEGVIubiquitination[1]
558VPMTPGVKQKIMSVIubiquitination[1]
560MTPGVKQKIMSVIREubiquitination[1]
588ATHDNPLKREEMHLEubiquitination[1]
628IEVASSVKLCRQAGIubiquitination[1]
645IMITGDNKGTAVAICubiquitination[1]
667QDEDVTSKAFTGREFubiquitination[1]
729NDAPALKKSEIGIAMubiquitination[1]
1013NYLEQPGKECVQPATubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Hydrolase; Membrane; Nucleotide-binding; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1061 AA 
Protein Sequence
ARRPRGREAR PAGAPAAMEN AHTKTVEEVL GHFGVNESTG LSLEQVKKLK ERWGSNELPA 60
EEGKTLLELV IEQFEDLLVR ILLLAACISF VLAWFEEGEE TITAFVEPFV ILLILVANAI 120
VGVWQERNAE NAIEALKEYE PEMGKVYRQD RKSVQRIKAK DIVPGDIVEI AVGDKVPADI 180
RLTSIKSTTL RVDQSILTGE SVSVIKHTDP VPDPRAVNQD KKNMLFSGTN IAAGKAMGVV 240
VATGVNTEIG KIRDEMVATE QERTPLQQKL DEFGEQLSKV ISLICIAVWI INIGHFNDPV 300
HGGSWIRGAI YYFKIAVALA VAAIPEGLPA VITTCLALGT RRMAKKNAIV RSLPSVETLG 360
CTSVICSDKT GTLTTNQMSV CRMFILDKVE GDTCSLNEFS ITGSTYAPIG EVQKDDKPVK 420
CHQYDGLVEL ATICALCNDS ALDYNEAKGV YEKVGEATET ALTCLVEKMN VFDTELKGLS 480
KIERANACNS VIKQLMKKEF TLEFSRDRKS MSVYCTPNKP SRTSMSKMFV KGAPEGVIDR 540
CTHIRVGSTK VPMTPGVKQK IMSVIREWGS GSDTLRCLAL ATHDNPLKRE EMHLEDSANF 600
IKYETNLTFV GCVGMLDPPR IEVASSVKLC RQAGIRVIMI TGDNKGTAVA ICRRIGIFGQ 660
DEDVTSKAFT GREFDELSPS AQRDACLNAR CFARVEPSHK SKIVEFLQSF DEITAMTGDG 720
VNDAPALKKS EIGIAMGSGT AVAKTASEMV LADDNFSTIV AAVEEGRAIY NNMKQFIRYL 780
ISSNVGEVVC IFLTAALGFP EALIPVQLLW VNLVTDGLPA TALGFNPPDL DIMNKPPRNP 840
KEPLISGWLF FRYLAIGCYV GAATVGAAAW WFIAADGGPR VSFYQLSHFL QCKEDNPDFD 900
GVDCAIFESP YPMTMALSVL VTIEMCNALN SLSENQSLLR MPPWENIWLV GSICLSMSLH 960
FLILYVEPLP LIFQITPLNL TQWLMVLKIS LPVILMDETL KFVARNYLEQ PGKECVQPAT 1020
KSSCSLSACT DGISWPFVLL IMPLVVWVYS TDTNFSDMFW S 1061 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0016529; C:sarcoplasmic reticulum; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005388; F:calcium-transporting ATPase activity; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0006874; P:cellular calcium ion homeostasis; IDA:MGI.
 GO:0006984; P:ER-nucleus signaling pathway; IMP:MGI.
 GO:0045822; P:negative regulation of heart contraction; IGI:MGI.
 GO:0006937; P:regulation of muscle contraction; TAS:MGI.
 GO:0002026; P:regulation of the force of heart contraction; IGI:MGI. 
Interpro
 IPR005782; ATPase_P-typ_Ca-transp_IIA.
 IPR006068; ATPase_P-typ_cation-transptr_C.
 IPR004014; ATPase_P-typ_cation-transptr_N.
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR018303; ATPase_P-typ_P_site.
 IPR023298; ATPase_P-typ_TM_dom.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom. 
Pfam
 PF00689; Cation_ATPase_C
 PF00690; Cation_ATPase_N
 PF00122; E1-E2_ATPase
 PF00702; Hydrolase 
SMART
 SM00831; Cation_ATPase_N 
PROSITE
 PS00154; ATPASE_E1_E2 
PRINTS
 PR00119; CATATPASE.
 PR00120; HATPASE.