CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031409
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear factor erythroid 2-related factor 1 
Protein Synonyms/Alias
 cDNA FLJ53241, highly similar to Nuclear factor erythroid 2-related factor 1 
Gene Name
 NFE2L1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
41FDYSHRQKEQDVEKEubiquitination[1, 2]
47QKEQDVEKELRDGGEubiquitination[1, 2]
441KIPFTNDKIINLPVEubiquitination[3, 4]
512KARLLREKVEFLRSLubiquitination[1]
525SLRQMKQKVQSLYQEubiquitination[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 584 AA 
Protein Sequence
MGWESHLTAA SADIDLIDIL WRQDIDLGAG REVFDYSHRQ KEQDVEKELR DGGEQDTWAG 60
EGAEALARNL LVDGETGESF PAQFPADISS ITEAVPSESE PPALQNNLLS PLLTGTESPF 120
DLEQQWQDLM SIMEMQAMEV NTSASEILYS APPGDPLSTN YSLAPNTPIN QNVSLHQASL 180
GGCSQDFLLF SPEVESLPVA SSSTLLPLAP SNSTSLNSTF GSTNLTGLFF PPQLNGTAND 240
TAGPELPDPL GGLLDEAMLD EISLMDLAIE EGFNPVQASQ LEEEFDSDSG LSLDSSHSPS 300
SLSSSEGSSS SSSSSSSSSS SASSSASSSF SEEGAVGYSS DSETLDLEEA EGAVGYQPEY 360
SKFCRMSYQD PAQLSCLPYL EHVGHNHTYN MAPSALDSAD LPPPSALKKG SKEKQADFLD 420
KQMSRDEHRA RAMKIPFTND KIINLPVEEF NELLSKYQLS EAQLSLIRDI RRRGKNKMAA 480
QNCRKRKLDT ILNLERDVED LQRDKARLLR EKVEFLRSLR QMKQKVQSLY QEVFGRLRDE 540
NGRPYSPSQY ALQYAGDGSV LLIPRTMADQ QARRQERKPK DRRK 584 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. 
Interpro
 IPR004827; bZIP.
 IPR008917; Euk_TF_DNA-bd. 
Pfam
 PF00170; bZIP_1 
SMART
 SM00338; BRLZ 
PROSITE
 PS50217; BZIP
 PS00036; BZIP_BASIC 
PRINTS