CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029750
UniProt Accession
Genbank Protein ID
 Z82188 
Genbank Nucleotide ID
  
Protein Name
 Ras-related C3 botulinum toxin substrate 2 
Protein Synonyms/Alias
  
Gene Name
 RAC2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
52SYENVRAKWFPEVRHubiquitination[1, 2]
72PIILVGTKLDLRDDKubiquitination[2, 3]
79KLDLRDDKDTIEKLKacetylation[3, 4]
79KLDLRDDKDTIEKLKmethylation[5]
79KLDLRDDKDTIEKLKubiquitination[2, 3, 6]
86KDTIEKLKEKKLAPImethylation[5]
89IEKLKEKKLAPITYPubiquitination[1, 2, 3]
103PQGLALAKEIDSVKYacetylation[3]
103PQGLALAKEIDSVKYubiquitination[1, 2, 3]
109AKEIDSVKYLECSALacetylation[3]
109AKEIDSVKYLECSALubiquitination[2]
122ALTQRGLKTVFDEAIubiquitination[1, 2, 3, 6]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 148 AA 
Protein Sequence
MVDSKPVNLG LWDTAGQEDY DRLRPLSYPQ TDVFLICFSL VSPASYENVR AKWFPEVRHH 60
CPSTPIILVG TKLDLRDDKD TIEKLKEKKL APITYPQGLA LAKEIDSVKY LECSALTQRG 120
LKTVFDEAIR AVLCPQPTRQ QKRACSLL 148 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0005635; C:nuclear envelope; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:InterPro.
 GO:0003924; F:GTPase activity; IEA:Compara.
 GO:0030036; P:actin cytoskeleton organization; IEA:Compara.
 GO:0045453; P:bone resorption; IEA:Compara.
 GO:0030031; P:cell projection assembly; IEA:Compara.
 GO:0006935; P:chemotaxis; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 
Pfam
 PF00071; Ras 
SMART
 SM00174; RHO 
PROSITE
 PS51420; RHO 
PRINTS
 PR00449; RASTRNSFRMNG.