CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006399
UniProt Accession
Genbank Protein ID
 M83196 
Genbank Nucleotide ID
Protein Name
 Microtubule-associated protein 1A 
Protein Synonyms/Alias
 MAP-1A; MAP1A heavy chain; MAP1 light chain LC2 
Gene Name
 Map1a 
Gene Synonyms/Alias
 Mtap1a 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
297RYPVATQKDLAAGAVubiquitination[1]
309GAVPANLKPSKIKHRubiquitination[1]
1722SPWTSDFKDFQEPLPubiquitination[1]
1731FQEPLPQKGLEVERWubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Structural protein involved in the filamentous cross- bridging between microtubules and other skeletal elements. 
Sequence Annotation
 REPEAT 336 338 1.
 REPEAT 415 417 2.
 REPEAT 420 422 3.
 REPEAT 424 426 4.
 REPEAT 427 429 5.
 REPEAT 431 433 6.
 REPEAT 436 438 7.
 REPEAT 440 442 8.
 REPEAT 444 446 9.
 REPEAT 449 451 10.
 REPEAT 539 541 11.
 REGION 336 541 11 X 3 AA repeats of K-K-[DE].
 MOD_RES 114 114 Phosphoserine (By similarity).
 MOD_RES 177 177 Phosphotyrosine (By similarity).
 MOD_RES 526 526 Phosphoserine (By similarity).
 MOD_RES 527 527 Phosphoserine (By similarity).
 MOD_RES 611 611 Phosphoserine (By similarity).
 MOD_RES 643 643 Phosphoserine (By similarity).
 MOD_RES 666 666 Phosphoserine (By similarity).
 MOD_RES 894 894 Phosphoserine (By similarity).
 MOD_RES 990 990 Phosphoserine (By similarity).
 MOD_RES 1002 1002 Phosphothreonine (By similarity).
 MOD_RES 1007 1007 Phosphoserine (By similarity).
 MOD_RES 1061 1061 Phosphoserine (By similarity).
 MOD_RES 1148 1148 Phosphoserine (By similarity).
 MOD_RES 1206 1206 Phosphoserine (By similarity).
 MOD_RES 1301 1301 Phosphoserine (By similarity).
 MOD_RES 1304 1304 Phosphoserine (By similarity).
 MOD_RES 1622 1622 Phosphoserine (By similarity).
 MOD_RES 1643 1643 Phosphoserine (By similarity).
 MOD_RES 1742 1742 Phosphoserine (By similarity).
 MOD_RES 1757 1757 Phosphoserine (By similarity).
 MOD_RES 1763 1763 Phosphoserine (By similarity).
 MOD_RES 1767 1767 Phosphoserine (By similarity).
 MOD_RES 1988 1988 Phosphoserine (By similarity).
 MOD_RES 2077 2077 Phosphoserine (By similarity).
 MOD_RES 2424 2424 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2774 AA 
Protein Sequence
MDGVAEFSEY VSETVDVPSP FDLLEPPTSG GFLKLSKPCC YIFPGGRGDS ALFAVNGFNI 60
LVDGGSDRKS CFWKLVRHLD RIDSVLLTHI GADNLPGING LLQRKVAELE EEQSQGSSSY 120
SDWVKNLISP ELGVVFFNVP DKLRLPDASR KAKRSIEEAC LTLQHLNRLG IQAEPLYRVV 180
SNTIEPLTLF HKMGVGRLDM YVLNPVKDSK EMQFLMQKWA GNSKAKTGIV LANGKEAEIS 240
VPYLTSITAL VVWLPANPTE KIVRVLFPGN APQNKILEGL EKLRHLDFLR YPVATQKDLA 300
AGAVPANLKP SKIKHRADSK ESLKAAPKTA VSKLAKREEV LEEGAKEARS ELAKELAKTE 360
KKAKEPSEKP PEKPSKSERV RGESSEALKA EKRRLIKDKA GKKHLKEKIS KLEEKKDKEK 420
KEIKKERKEL KKEEGRKEEK KDAKKDEKRK DTKPEVKKLS KPDLKPFTPE VRKTLYKAKA 480
PGRVKVDKGR AARGEKELSS EPRTPPAQKG AAPPAAVSGH RELALSSPED LTQDFEELKR 540
EERGLLAEQR DTGLGEKPLP ADATEQGHPS AAIQVTQPSG PVLEGEHVER EKEVVPDSPG 600
DKGSTNRGPD SGAEVEKEKE TWEERKQREA ELGPENTAAR EESEAEVKED VIEKAELEEM 660
EETHPSDEEG EETKAESFYQ KHTQEALKAS PKSREALGGR DLGFQGKAPE KETASFLSSL 720
ATPAGATEHV SYIQDETIPG YSETEQTISD EEIHDEPDER PAPPRFPTST YDLSGPEGPG 780
PFEASQAADS AVPASSSKTY GAPETELTYP PNMVAAPLAE EEHVSSATSI TECDKLSSFA 840
TSVAEDQSVA SLTAPQTEET GKSSLLLDTV TSIPSSRTEA TQGLDYVPSA GTISPTSSLE 900
EDKGFKSPPC EDFSVTGESE KKGETVGRGL SGEKAVGKEE KYVVTSEKLS GQYAAVFGAP 960
GHTLPPGEPA LGEVEERCLS PDDSTVKMAS PPPSGPPSAA HTPFHQSPVE DKSEPRDFQE 1020
DSWGETKHSP GVSKEDSEEQ TVKPGPEEGT SEEGKGPPTR SPQAQDMPVS IAGGQTGCTI 1080
QLLPEQDKAI VFETGEAGSN LGAGTLPGEV RTSTEEATEP QKDEVLRFTD QSLSPEDAES 1140
LSVLSVVSPD TTKQEATPRS PCSLKEQQPH KDLWPMVSPE DTQSLSFSEE SPSKETSLDI 1200
SSKQLSPESL GTLQFGELNL GKEERGPVMK AEDDSCHLAP VSIPEPHRAT VSPSTDETPA 1260
GTLPGGSFSH SALSVDRKHS PGEITGPGGH FMTSDSSLTK SPESLSSPAM EDLAVEWEGK 1320
APGKEKEPEL KSETRQQKGQ ILPEKVAVVE QDLIIHQKDG ALDEENKPGR QQDKTPEQKG 1380
RDLDEKDTAA ELDKGPEPKE KDLDREDQGQ RAGPPAEKDK ASEQRDTDLQ QTQATEPRDR 1440
AQERRDSEEK DKSLELRDRT PEEKDRILVQ EDRAPEHSIP EPTQTDRAPD RKGTDDKEQK 1500
EEASEEKEQV LEQKDWALGK EGETLDQEAR TAEQKDETLK EDKTQGQKSS FVEDKTTTSK 1560
ETVLDQKSAE KADSVEQQDG AALEKTRALG LEESPAEGSK AREQEKKYWK EQDVVQGWRE 1620
TSPTRGEPVG GQKEPVPAWE GKSPEQEVRY WRDRDITLQQ DAYWRELSCD RKVWFPHELD 1680
GQGARPRYCE ERESTFLDEG PDEQEITPLQ HTPRSPWTSD FKDFQEPLPQ KGLEVERWLA 1740
ESPVGLPPEE EDKLTRSPFE IISPPASPPE MTGQRVPSAP GQESPVPDTE STAPMRNEPT 1800
TPSWLAEIPP WVPKDRPLPP APLSPAPAPP TPAPEPHTPV PFSWGLAEYD SVVAAVQEGA 1860
AELEGGPYSP LGKDYRKAEG EREGEGGAGA PDSSSFSPKV PEAGESLATR DTEQTEPEQR 1920
EPTPYPDERS FQYADIYEQM MLTGLGPACP TREPPLGASG DWPPHLSTKE EAAGCNTSAE 1980
KETSSPASPQ NLQSDTPAFS YASLAGPAVP PRQEPDPGPN VEPSITPPAV PPRAPISLSK 2040
DLSPPLNGST VSCSPDRRTP SPKETGRGHW DDGTNDSDLE KGAREQPEKE TRSPSPHHPM 2100
PMGHSSLWPE TEAYSSLSSD SHLGSVRPSL DFPASAFGFS SLQPAPPQLP SPAEPRSAPC 2160
GSLAFSGDRA LALVPGTPTR TRHDEYLEVT KAPSLDSSLP QLPSPSSPGG PLLSNLPRPA 2220
SPALSEGSSS EATTPVISSV AERFPPGLEA AEQSAEGLGS GKESAAHSLW DLTPLSPAPS 2280
ASLDLAPAPA PAPAPAPGLP GDLGDGTLPC RPECTGELTK KPSPFLSPSG DHEANGPGET 2340
SLNPPGFVTA TAEKEEAEAP HAWERGSWPE GAERSSRPDT LLSSEQPLRP GKSSGGPPCS 2400
LSSEVEAGPQ GCATDPRPHC GELSPSFLNP PLPPSTDDSD LSTEEARLAG KGGRRRVGRP 2460
GATGGPCPMA DETPPTSASD SGSSQSDSDV PPETEECPSI TAEAALDSDE DGDFLPVDKA 2520
GGVSGTHHPR PGHDPPPTPL PDPRPSPPRP DVCMADPEGL SSESGRVERL REKGRPGRRA 2580
PGRAKPASPA RRLDIRGKRS PTPGKGPVDR TSRTVPRPRS TPSQVTSAEE KDGHSPMSKG 2640
LVNGLKAGST ALGSKGGSGP PVYVDLAYIP NHCSGKTADQ DFFRRVRASY YVVSGNDPAN 2700
GEPSRAVLDA LLEGKAQWGE NLQVTLIPTH DTEVTREWYQ QTHEQQQQLN VLVLASSSTV 2760
VMQDESFPAC KIEF 2774 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005875; C:microtubule associated complex; IDA:RGD.
 GO:0003779; F:actin binding; IDA:RGD.
 GO:0016787; F:hydrolase activity; IEA:InterPro.
 GO:0000226; P:microtubule cytoskeleton organization; IEA:InterPro.
 GO:0007026; P:negative regulation of microtubule depolymerization; IDA:RGD. 
Interpro
 IPR001279; Beta-lactamas-like.
 IPR026074; MAP1.
 IPR015656; MAP1A. 
Pfam
  
SMART
  
PROSITE
  
PRINTS