CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041866
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Intraflagellar transport 88 homolog (Chlamydomonas) 
Protein Synonyms/Alias
 Intraflagellar transport protein 88 homolog 
Gene Name
 Ift88 
Gene Synonyms/Alias
 mCG_127043 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
444DTLKMFEKKDSRVKSacetylation[1]
491NPSALTNKGNTVFANubiquitination[2]
806RPKTAAKKRIDEDDFacetylation[3]
Reference
 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Cell projection; Cilium; Complete proteome; Flagellum; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 825 AA 
Protein Sequence
MMENVHLAPE TDEDDLYSGF NDYNPAYDTE ELENDTGFQQ AVRTSHGRRP PVTAKIPSTA 60
VSRPIATGYG SKTSLTSSMG RPMTGTIQDG VARPMTAVRA AGFSKAALRG SAFDPLGQSR 120
GPAPPLEAKN EDSPEEKIRQ LEKKVNELVE ESCIANSCGD LKLALEKAKD AGRKERVLVR 180
QREQVTSPEN INLDLTYSVL FNLASQYSAN EMYAEALNTY QVIVKNKMFS NAGRLKVNMG 240
NIYLKQRNYS KAIKFYRMAL DQIPSVHKEM RIKIMQNIGI TFIKTGQYSD AINSFEHIMS 300
MAPSLKAGFN LILSCFAIGD REKMKKAFQK LIAVPLEIDE DDKYISPSDD PHTNLLIEAI 360
KNDHLRQMER ERKAMAEKYI MTAAKLIAPV IEASFAVGYN WCVEVVKASQ YVELANDLEI 420
NKAITYLRQK DFNQAVDTLK MFEKKDSRVK SAAATNLSFL YYLENEFAQA SSYADLAVNS 480
DRYNPSALTN KGNTVFANGD YEKAAEFYKE ALRNDSSCTE ALYNIGLTYK KLNRLDEALD 540
SFLKLHAILR NSAQVLCQIA NIYELMEDPN QAIEWLMQLI SVVPTDSQAL SKLGELYDSE 600
GDKSQAFQYY YESYRYFPSN IEVIEWLGAY YIDTQFCEKA IQYFERASLI QPTQVKWQLM 660
VASCFRRSGN YQKALDTYKE IHRKFPENVE CLRFLVRLCT DIGLKEVQEY ATKLKRLEKM 720
KEMREQRIKS GRDSSGGSRS KREGSAGSDS GQNNSASSKS ERLSAKLRAL PGTDEPYESS 780
GNKEIDASYV DPLGPQIERP KTAAKKRIDE DDFADEELGD DLLPE 825 
Gene Ontology
 GO:0035085; C:cilium axoneme; IDA:MGI.
 GO:0005932; C:microtubule basal body; IDA:MGI.
 GO:0031512; C:motile primary cilium; IDA:MGI.
 GO:0032391; C:photoreceptor connecting cilium; IDA:MGI.
 GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
 GO:0060411; P:cardiac septum morphogenesis; IMP:MGI.
 GO:0060271; P:cilium morphogenesis; IMP:MGI.
 GO:0007368; P:determination of left/right symmetry; IMP:MGI.
 GO:0042733; P:embryonic digit morphogenesis; IMP:MGI.
 GO:0048568; P:embryonic organ development; IMP:MGI.
 GO:0003382; P:epithelial cell morphogenesis; IMP:MGI.
 GO:0001654; P:eye development; IGI:MGI.
 GO:0048853; P:forebrain morphogenesis; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0060426; P:lung vasculature development; IMP:MGI.
 GO:0060021; P:palate development; IGI:MGI.
 GO:0045862; P:positive regulation of proteolysis; IMP:MGI.
 GO:0008104; P:protein localization; IMP:MGI.
 GO:0016485; P:protein processing; IMP:MGI.
 GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IMP:MGI.
 GO:0007224; P:smoothened signaling pathway; IMP:MGI.
 GO:0021513; P:spinal cord dorsal/ventral patterning; IMP:MGI.
 GO:0021537; P:telencephalon development; IMP:MGI. 
Interpro
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00515; TPR_1
 PF13174; TPR_6 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS