CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016572
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aspartyl/asparaginyl beta-hydroxylase 
Protein Synonyms/Alias
 Aspartate beta-hydroxylase; ASP beta-hydroxylase; Peptide-aspartate beta-dioxygenase 
Gene Name
 Asph 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
119AKVLLGLKERSPSERubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. 
Sequence Annotation
 REPEAT 324 357 TPR 1.
 REPEAT 365 398 TPR 2.
 REPEAT 437 470 TPR 3.
 REPEAT 472 504 TPR 4.
 REPEAT 508 540 TPR 5.
 CARBOHYD 453 453 N-linked (GlcNAc...) (Potential).
 CARBOHYD 689 689 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Dioxygenase; Endoplasmic reticulum; Glycoprotein; Iron; Membrane; Oxidoreductase; Reference proteome; Repeat; Signal-anchor; TPR repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 741 AA 
Protein Sequence
MAPRKNAKGG GGNSSSSGSG SGSGSGSPST GSSGSSSSPG ARREAKHGGH KNGRRGGISG 60
GSFFTWFMVI ALLGVWTSVA VVWFDLVDYE EVLGKLGVYD ADGDGDFDVD DAKVLLGLKE 120
RSPSERTFPP EEEAETHAEL EEQAPEGADI QNVEDEVKEQ IQSLLQESVH TDHDLEADGL 180
AGEPQPEVED FLTVTDSDDR FEDLEPGTVH EEIEDTYHVE DTASQNHPND MEEMTNEQEN 240
SDPSEAVTDA GVLLPHAEEV RHQDYDEPVY EPSEHEGVAI SDNTIDDSSI ISEEINVASV 300
EEQQDTPPVK KKKPKLLNKF DKTIKAELDA AEKLRKRGKI EEAVNAFEEL VRKYPQSPRA 360
RYGKAQCEDD LAEKQRSNEV LRRAIETYQE AADLPDAPTD LVKLSLKRRS ERQQFLGHMR 420
GSLLTLQRLV QLFPSDTTLK NDLGVGYLLL GDNDSAKKVY EEVLNVTPND GFAKVHYGFI 480
LKAQNKISES IPYLKEGIES GDPGTDDGRF YFHLGDAMQR VGNKEAYKWY ELGHKRGHFA 540
SVWQRSLYNV NGLKAQPWWT PRETGYTELV KSLERNWKLI RDEGLMVMDK AKGLFLPEDE 600
NLREKGDWSQ FTLWQQGRKN ENACKGAPKT CALLEKFSET TGCRRGQIKY SIMHPGTHVW 660
PHTGPTNCRL RMHLGLVIPK EGCKIRCANE TRTWEEGKVL IFDDSFEHEV WQDASSFRLI 720
FIVDVWHPEL TPQQRRSLPA I 741 
Gene Ontology
 GO:0032541; C:cortical endoplasmic reticulum; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:BHF-UCL.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; ISS:MGI.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW.
 GO:0004597; F:peptide-aspartate beta-dioxygenase activity; ISS:MGI.
 GO:0032237; P:activation of store-operated calcium channel activity; IEA:Compara.
 GO:0070588; P:calcium ion transmembrane transport; IEA:Compara.
 GO:0071277; P:cellular response to calcium ion; IEA:Compara.
 GO:0060325; P:face morphogenesis; IMP:MGI.
 GO:0035108; P:limb morphogenesis; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IGI:MGI.
 GO:0060021; P:palate development; IMP:MGI.
 GO:0007389; P:pattern specification process; IMP:MGI.
 GO:0042264; P:peptidyl-aspartic acid hydroxylation; IDA:MGI.
 GO:0010524; P:positive regulation of calcium ion transport into cytosol; IEA:Compara.
 GO:0090316; P:positive regulation of intracellular protein transport; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0031585; P:regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:Compara.
 GO:1901879; P:regulation of protein depolymerization; IDA:BHF-UCL.
 GO:0031647; P:regulation of protein stability; IDA:BHF-UCL.
 GO:0033198; P:response to ATP; IEA:Compara. 
Interpro
 IPR007943; Asp-B-hydro/Triadin_dom.
 IPR007803; Asp_Arg_b-Hydrxlase.
 IPR027443; IPNS-like.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 
Pfam
 PF05279; Asp-B-Hydro_N
 PF05118; Asp_Arg_Hydrox
 PF07719; TPR_2 
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS