CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005274
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphomannomutase 
Protein Synonyms/Alias
 PMM 
Gene Name
 manB 
Gene Synonyms/Alias
 cpsG; rfbL; b2048; JW2033 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
15KAYDIRGKLGEELNEacetylation[1]
37RAYGEFLKPKTIVLGacetylation[1]
166LFGYINVKNLTPLKLacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Involved in the biosynthesis of the capsular polysaccharide colanic acid. 
Sequence Annotation
 ACT_SITE 98 98 Phosphoserine intermediate (By
 METAL 98 98 Magnesium; via phosphate group (By
 METAL 245 245 Magnesium (By similarity).
 METAL 247 247 Magnesium (By similarity).
 METAL 249 249 Magnesium (By similarity).  
Keyword
 Capsule biogenesis/degradation; Complete proteome; Isomerase; Lipopolysaccharide biosynthesis; Magnesium; Metal-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 456 AA 
Protein Sequence
MKKLTCFKAY DIRGKLGEEL NEDIAWRIGR AYGEFLKPKT IVLGGDVRLT SETLKLALAK 60
GLQDAGVDVL DIGMSGTEEI YFATFHLGVD GGIEVTASHN PMDYNGMKLV REGARPISGD 120
TGLRDVQRLA EANDFPPVDE TKRGRYQQIN LRDAYVDHLF GYINVKNLTP LKLVINSGNG 180
AAGPVVDAIE ARFKALGAPV ELIKVHNTPD GNFPNGIPNP LLPECRDDTR NAVIKHGADM 240
GIAFDGDFDR CFLFDEKGQF IEGYYIVGLL AEAFLEKNPG AKIIHDPRLS WNTVDVVTAA 300
GGTPVMSKTG HAFIKERMRK EDAIYGGEMS AHHYFRDFAY CDSGMIPWLL VAELVCLKDK 360
TLGELVRDRM AAFPASGEIN SKLAQPVEAI NRVEQHFSRE ALAVDRTDGI SMTFADWRFN 420
LRTSNTEPVV RLNVESRGDV PLMEARTRTL LTLLNE 456 
Gene Ontology
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0004615; F:phosphomannomutase activity; IEA:EC.
 GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW. 
Interpro
 IPR005844; A-D-PHexomutase_a/b/a-I.
 IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
 IPR005845; A-D-PHexomutase_a/b/a-II.
 IPR005846; A-D-PHexomutase_a/b/a-III.
 IPR005843; A-D-PHexomutase_C.
 IPR016066; A-D-PHexomutase_CS.
 IPR005841; Alpha-D-phosphohexomutase_SF. 
Pfam
 PF02878; PGM_PMM_I
 PF02879; PGM_PMM_II
 PF02880; PGM_PMM_III
 PF00408; PGM_PMM_IV 
SMART
  
PROSITE
 PS00710; PGM_PMM 
PRINTS
 PR00509; PGMPMM.