CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005591
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanine nucleotide-binding protein subunit alpha-12 
Protein Synonyms/Alias
 G alpha-12; G-protein subunit alpha-12 
Gene Name
 Gna12 
Gene Synonyms/Alias
 Gna-12 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
101TIFDNILKGSRVLVDubiquitination[1]
196QLNYFPSKQDILLARubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. 
Sequence Annotation
 NP_BIND 62 69 GTP (By similarity).
 NP_BIND 200 206 GTP (By similarity).
 NP_BIND 225 229 GTP (By similarity).
 NP_BIND 294 297 GTP (By similarity).
 METAL 69 69 Magnesium (By similarity).
 METAL 206 206 Magnesium (By similarity).
 BINDING 351 351 GTP; via amide nitrogen (By similarity).
 MOD_RES 38 38 Phosphoserine.
 LIPID 11 11 S-palmitoyl cysteine.  
Keyword
 3D-structure; Complete proteome; GTP-binding; Lipoprotein; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Palmitate; Phosphoprotein; Reference proteome; Transducer. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 379 AA 
Protein Sequence
MSGVVRTLSR CLLPAEAGAR ERRAGAARDA EREARRRSRD IDALLARERR AVRRLVKILL 60
LGAGESGKST FLKQMRIIHG REFDQKALLE FRDTIFDNIL KGSRVLVDAR DKLGIPWQHS 120
ENEKHGMFLM AFENKAGLPV EPATFQLYVP ALSALWRDSG IREAFSRRSE FQLGESVKYF 180
LDNLDRIGQL NYFPSKQDIL LARKATKGIV EHDFVIKKIP FKMVDVGGQR SQRQKWFQCF 240
DGITSILFMV SSSEYDQVLM EDRRTNRLVE SMNIFETIVN NKLFFNVSII LFLNKMDLLV 300
EKVKSVSIKK HFPDFKGDPH RLEDVQRYLV QCFDRKRRNR SKPLFHHFTT AIDTENIRFV 360
FHAVKDTILQ ENLKDIMLQ 379 
Gene Ontology
 GO:0031526; C:brush border membrane; IBA:RefGenome.
 GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome.
 GO:0031752; F:D5 dopamine receptor binding; IBA:RefGenome.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; ISA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; IBA:RefGenome.
 GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IBA:RefGenome.
 GO:0030154; P:cell differentiation; IDA:MGI.
 GO:0042733; P:embryonic digit morphogenesis; IGI:MGI.
 GO:0001701; P:in utero embryonic development; IGI:MGI.
 GO:0007243; P:intracellular protein kinase cascade; IDA:MGI.
 GO:0008360; P:regulation of cell shape; IDA:MGI.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0007266; P:Rho protein signal transduction; IDA:MGI. 
Interpro
 IPR000469; Gprotein_alpha_12.
 IPR001019; Gprotein_alpha_su.
 IPR011025; GproteinA_insert.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00503; G-alpha 
SMART
 SM00275; G_alpha 
PROSITE
  
PRINTS
 PR00318; GPROTEINA.
 PR00440; GPROTEINA12.