UniProt Accession

 CDK10_HUMAN; Q15131; A8MXU6; B7Z420; D3DX82; D3DX83; Q0VGZ7; Q15130; Q6PJC0 

Genbank Protein ID

 L33264; X78342; AJ010341; AJ010342; AJ010343; AJ010344; AM392903; AK296631; AM393177; AM393204; AC010538; CH471184; CH471184; CH471184; CH471184; CH471184; CH471184; BC017342; BC025301 

Genbank Nucleotide ID

 AAA60092.2; CAA55137.1; CAB37619.1; CAB37619.1; CAB37619.1; CAB37619.1; CAL37781.1; BAH12406.1; CAL38055.1; CAL38082.1; EAW66701.1; EAW66703.1; EAW66704.1; EAW66706.1; EAW66707.1; EAW66708.1; AAH17342.1; AAH25301.1 

Protein Name

 Cyclin-dependent kinase 10 

Protein Synonyms/Alias

 Cell division protein kinase 10; Serine/threonine-protein kinase PISSLRE 

Gene Name

 CDK10 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
41	RSVKEFEKLNRIGEG	ubiquitination	[1]
68	TDEIVALKKVRMDKE	ubiquitination	[2]
69	DEIVALKKVRMDKEK	ubiquitination	[1]
76	KVRMDKEKDGIPISS	ubiquitination	[3]
178	MTDKGCVKTADFGLA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

 DOMAIN 39 323 Protein kinase.
 NP_BIND 45 53 ATP (By similarity).
 ACT_SITE 163 163 Proton acceptor (By similarity).
 BINDING 68 68 ATP (By similarity).
 MOD_RES 196 196 Phosphothreonine.  

Keyword

 Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 360 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; TAS:ProtInc.
 GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
 GO:0007089; P:traversing start control point of mitotic cell cycle; TAS:ProtInc. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS