Tag | Content |
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CPLM ID | CPLM-002567 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Aldose reductase |
Protein Synonyms/Alias | AR; Aldehyde reductase |
Gene Name | Akr1b1 |
Gene Synonyms/Alias | Akr1b4; Aldr1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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12 | LELNNGTKMPTLGLG | acetylation | [1] | 53 | AQVYQNEKEVGVALQ | acetylation | [1] | 222 | SPDRPWAKPEDPSLL | acetylation | [1] | 240 | RIKEIAAKYNKTTAQ | acetylation | [1] | 263 | RNLVVIPKSVTPARI | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. |
Sequence Annotation | NP_BIND 10 19 NADP (Potential). NP_BIND 211 273 NADP (By similarity). ACT_SITE 49 49 Proton donor (By similarity). BINDING 111 111 Substrate (By similarity). MOD_RES 2 2 N-acetylalanine (By similarity). MOD_RES 95 95 N6-acetyllysine (By similarity). MOD_RES 222 222 N6-acetyllysine (By similarity). MOD_RES 263 263 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; NADP; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 316 AA |
Protein Sequence | MASHLELNNG TKMPTLGLGT WKSPPGQVTE AVKVAIDMGY RHIDCAQVYQ NEKEVGVALQ 60 EKLKEQVVKR QDLFIVSKLW CTFHDQSMVK GACQKTLSDL QLDYLDLYLI HWPTGFKPGP 120 DYFPLDASGN VIPSDTDFVD TWTAMEQLVD EGLVKAIGVS NFNPLQIERI LNKPGLKYKP 180 AVNQIECHPY LTQEKLIEYC HCKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKEIAAK 240 YNKTTAQVLI RFPIQRNLVV IPKSVTPARI AENFKVFDFE LSNEDMATLL SYNRNWRVCA 300 LMSCAKHKDY PFHAEV 316 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005615; C:extracellular space; IDA:RGD. GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:RGD. GO:0046427; P:positive regulation of JAK-STAT cascade; IMP:RGD. GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD. GO:0010033; P:response to organic substance; IDA:RGD. GO:0006061; P:sorbitol biosynthetic process; IMP:RGD. GO:0031098; P:stress-activated protein kinase signaling cascade; IMP:RGD. |
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