CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011093
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase TDA1 
Protein Synonyms/Alias
 Topoisomerase I damage affected protein 1 
Gene Name
 TDA1 
Gene Synonyms/Alias
 YMR291W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
561DYDTTNDKNPARKHAubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Serine/threonine protein kinase shown to have protein phosphorylation activity in vitro. 
Sequence Annotation
 DOMAIN 39 351 Protein kinase.
 NP_BIND 45 53 ATP (By similarity).
 ACT_SITE 180 180 Proton acceptor (By similarity).
 BINDING 68 68 ATP (By similarity).
 MOD_RES 504 504 Phosphothreonine.
 MOD_RES 509 509 Phosphoserine.
 MOD_RES 538 538 Phosphothreonine.
 MOD_RES 578 578 Phosphoserine.  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 586 AA 
Protein Sequence
MTTASSSASQ LQQRLPEEKP WPQLSGSNAD AQTFKCKYVT NHNSLGDGNF SVVKECMNIH 60
TKDLYAMKLI KKQTVKNKIQ LIQREFDLLR SISEKIRDME KKNEHSLDIF EGHHHILQLF 120
DYFETADNIV LITQLCQKGD LYEKIVENQC LDLETQVTSY CACLVSVLEF LHSQGIVHRD 180
LKAENVLFRL RVNENEKNLQ GEHHGDFKYD LLAHDLVLAD FGLAAEYNTS KVNSLKEFVG 240
TISYIAPEIV KCKGVGEMTP DQVGKLDKYG CPVDIWALGV LTYFMAFGYT PFDCTTDDET 300
LECISKCDYY VDEQMMHDPK YEQFWNFVQC CFTIDPAVRR SAKNLKQHPF IKDYFATSNS 360
LNTKDTPNFS FHPTIRRVSS TASMHTLRSP SKSRKTTTLA YLNMDGGSSE TSTAFSSKMD 420
LPDLYVDRTI NSRERSLNRI RDTLKKTLSM TSLKPAGTFD YLHANKNGTS LSSSKSGLVK 480
KNSTFVLDPK PPKNSLMNGC FSTTPESRSN FNTPKTLSRQ GSSTSVKKYV NEVDLLLTPR 540
TASMSSNDTT AINDYDTTND KNPARKHAAS FQVNVDDSDG DETMQI 586 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004672; F:protein kinase activity; IDA:SGD.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR020675; Myosin_light_ch_kinase-rel.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS.
 IPR020679; Ser/Thr_kinase_YMR291W_prd. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS