CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042478
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Neurobeachin-like protein 2 
Protein Synonyms/Alias
  
Gene Name
 NBEAL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26PGGAEAGKARHAGAVubiquitination[1]
305PNETAPFKPEGELHEubiquitination[1]
327HYSPQACKNNICLDLubiquitination[1]
411GLVLPLGKSSEERMEubiquitination[1, 2]
530EHRQKLRKKYGVQFIubiquitination[1]
531HRQKLRKKYGVQFILubiquitination[1]
781VRPPDCIKRSLLEMMubiquitination[1]
912EACYVLSKLEAALGRubiquitination[1, 3, 4]
1004EWRHFIDKQVQPTMSubiquitination[1, 2]
1116DTPIPRWKLSSAETYubiquitination[1, 4, 5]
1129TYSRMRLKLVPNHHFubiquitination[1, 4]
1171LAVTKEAKVSTPPELubiquitination[1]
1355RASGLTQKWVQREISubiquitination[1, 4, 5, 6]
1412AVFRDLSKPIGVVNPubiquitination[1, 4]
1420PIGVVNPKHAQLVREubiquitination[1, 4, 5]
1428HAQLVREKYESFEDPubiquitination[1, 4, 6]
1441DPAGTIDKFHYGTHYubiquitination[1]
1609VTDERERKALEGIISubiquitination[1, 4]
1627QTPCQLLKEPHPTRLubiquitination[1, 4]
1725SNYFSFSKDPTMGSHubiquitination[1]
1760LAVAPDGKLLFSGGHubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2042 AA 
Protein Sequence
XPMELRHLLR PRPGLDSEPG GAEAGKARHA GAVIRTLSGM ARHQGPARAL RYFDLTPSMA 60
GIMVPPVQRW PGPGFTFHAW LCLHPMDTAP TPAPTRPLQR KQLYSFFTSS GSGFEAFFTA 120
AGTLVVAVCT RKEYLTMSLP EVSFADSAWH CVAIVHVPGR RPFSQNLVHV YKDGHLVKTA 180
PLRCPSLSEP FSSCCIGSAG YRTTTTTTGL PTPPVPATLA YTHPALTRSQ SVPASTGLGW 240
GSGLVAPLQE GSIDSTLAGT QDTRWGSPTS LEGELGAVAI FHEALQATAL RTLCTLGPNE 300
TAPFKPEGEL HELSTRLLLH YSPQACKNNI CLDLSPSHGL DGRLTGHRVE TWDVKDVVNC 360
VGGMGALLPL LERVAAQPKE AEAGPAETHD LVGPELTSGH NTQGLVLPLG KSSEERMERN 420
AVAAFLLMLR NFLQGHMVNQ ESLVQCQGPA IIGALLRKVP SWAMDMNVLM SAQLLMEQVA 480
AEGSGPLLYL LYQHLLFNFH LWTLSDFAVR LGHIQYMSSI VREHRQKLRK KYGVQFILDA 540
LRTHYSPQRE RPLAADDLRT VQTSLLGLAR EFLVRSLSAD DVQVTQTMLS FLAATGDDGQ 600
ILRRLQQNER LPERSRQRLR LRECGLQGLV ACLPEGTVSP QLCQGLYKLF LGAGSGNTAG 660
GGGSSGTLTP ASQPGTPSPL DGPRPFPAAP GRHSSSLSNV LEDGSLPEPT ISGDDTSNTS 720
NPQQTSEEEL CNLLTNVLFS VTWRGVEGSD EAAWRERGQV FSVLTQLGAS ATLVRPPDCI 780
KRSLLEMMLE SALTDIKEAP VGVLASLTQQ ALWLLRLLQD FLCAEGHGNQ ELWSEKLFEG 840
VCSLLDRLGA WPHLANGTAD LREMAQIGLR LVLGYILLED PQLHAQAYVR LHMLLQTAVP 900
ARREEACYVL SKLEAALGRV LNTSSLESAT DEAGSPLAAA AAAAAAERCS WLVPLVRTLL 960
DRAYEPLGLQ WGLPSLPPTN GSPTFFEDFQ AFCATPEWRH FIDKQVQPTM SQFEMDTYAK 1020
SHDLMSGFWN ACYDMLMSSG QRRQWERAQS RRAFQELVLE PAQRRARLEG LRYTAVLKQQ 1080
ATQHSMALLH WGALWRQLAS PCGAWALRDT PIPRWKLSSA ETYSRMRLKL VPNHHFDPHL 1140
EASALRDNLG EVPLTPTEEA SLPLAVTKEA KVSTPPELLQ EDQLGEDELA ELETPMEAAE 1200
LDEQREKLVL SAECQLVTVV AVVPGLLEVT TQNVYFYDGS TERVETEEGI GYDFRRPLAQ 1260
LREVHLRRFN LRRSALELFF IDQANYFLNF PCKVGTTPVS SPSQTPRPQP GPIPPHTQVR 1320
NQVYSWLLRL RPPSQGYLSS RSPQEMLRAS GLTQKWVQRE ISNFEYLMQL NTIAGRTYND 1380
LSQYPVFPWV LQDYVSPTLD LSNPAVFRDL SKPIGVVNPK HAQLVREKYE SFEDPAGTID 1440
KFHYGTHYSN AAGVMHYLIR VEPFTSLHVQ LQSGRFDCSD RQFHSVAAAW QARLESPADV 1500
KELIPEFFYF PDFLENQNGF DLGCLQLTNE KVGDVVLPPW ASSPEDFIQQ HRQALESEYV 1560
SAHLHEWIDL IFGYKQRGPA AEEALNVFYY CTYEGAVDLD HVTDERERKA LEGIISNFGQ 1620
TPCQLLKEPH PTRLSAEEAA HRLARLDTNS PSIFQHLDEL KAFFAEVVSD GVPLVLALVP 1680
HRQPHSFITQ GSPDLLVTVS ASGLLGTHSW LPYDRNISNY FSFSKDPTMG SHKTQRLLSG 1740
PWVPGSGVSG QALAVAPDGK LLFSGGHWDG SLRVTALPRG KLLSQLSCHL DVVTCLALDT 1800
CGIYLISGSR DTTCMVWRLL HQGGLSVGLA PKPVQVLYGH GAAVSCVAIS TELDMAVSGS 1860
EDGTVIIHTV RRGQFVAALR PLGATFPGPI FHLALGSEGQ IVVQSSAWER PGAQVTYSLH 1920
LYSVNGKLRA SLPLAEQPTA LTVTEDFVLL GTAQCALHIL QLNTLLPAAP PLPMKVAIRS 1980
VAVTKERSHV LVGLEDGKLI VVVAGQPSEV RSSQFARKLW RSSRRISQVS SGETEYNPTE 2040
AR 2042 
Gene Ontology
  
Interpro
 IPR000409; BEACH_dom.
 IPR008985; ConA-like_lec_gl_sf.
 IPR026916; NBEAL.
 IPR023362; PH-BEACH_dom.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF02138; Beach
 PF00400; WD40 
SMART
 SM01026; Beach
 SM00320; WD40 
PROSITE
 PS50197; BEACH
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS