| Tag | Content |
|---|
| CPLM ID | CPLM-016044 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Integrator complex subunit 2 |
Protein Synonyms/Alias | Int2 |
Gene Name | Ints2 |
Gene Synonyms/Alias | Kiaa1287 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 840 | IKFIRQQKYTQNDLM | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity). |
Sequence Annotation | |
Keyword | Alternative splicing; Complete proteome; Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1198 AA |
Protein Sequence | MTPEGTGLQF VSPFAFEAMQ KVDVVRLASL SDPELRLLLP CLVRMALCAP ADQSQSWAQD 60
KKLILRLLSG VEAVNSIVAL LSVDFHALEQ DASKEQQLRH KLGGGSGESI LVSQLQHGLT 120
LEFEHSDSPR RLRLVLSELL AIMNKVSECN GEFFFKSSEL FESAVYLEEA ADVLCILQAE 180
LPSLLPIVDV AEALLRVRNG AWFLCLLVAN VPDSFNEVCR GLIKNGERQD EESLGGRRRT 240
DALRFLCRMN PSQALKVRGM VVEECHLPGL GVALTLDHTK TEACEDGVSD LVCFVSGLLL 300
GTNAKVRTWF GTFIRNGQQR KRETSGSVLW QMRRQLLLEL MGILPTVRST RIVEEADVEM 360
EPTVSVYSGL KEEHVVKASA LLRLYCALMG IAGLKPTEEE AEQLLQLMTS RPPATPAGVR 420
FVSLSFCMLL AFSTLVSTPE QEQLMVLWLS WMIKEEAYFE STSGVSASFG EMLLLVAMYF 480
HSNQLSAIID LVCSTLGMKI VIKPSSLSRM KTIFTQEIFT EQVVTAHAVR VPVTSNLSAN 540
ITGFLPIHCI YQLLRSRSFT KHKVSIKDWI YRQLCETSTP LHPQLLPLID VYINSILTPA 600
SKSNPEATNQ PVTEQEILNL FQEVIGGDSV RLTQRFSITA QLLVLYYILS YEEALLANTK 660
TLASMQRKPK SYSSSLMDQI PIKFLIRQAQ GLQQELGGLH SALLRLLATN YPHLCIVDDW 720
ICEEEITGTD ALLRRMLLTS NAKTHSPKQL QEAFSAVPVS HTQVMQIMEH LTLLSASELI 780
PYAEVLTSNM NQLLNSGVPR RILQTVNKLW MVLNTVMPRR LWVMTVNALQ PSIKFIRQQK 840
YTQNDLMIDP LIVLRCDRRV HRCPPLMDVT LHMLNGYLLA SKAYLSAHLK ETAEQDRPSP 900
NNTVGLVGQT DAPEVTREEL KNALLAAQDS AAVQILLEIC LPTEEEKAKG ANSDISLRNT 960
QGVTTISTPS KETEEGEDNL LCNLREVQCL ICCLLHQMYI ADPNIAKLVH FQGYPCELLP 1020
LTVAGIPSMH ICLDFIPELI AQPELEKQIF AIQLLSHLCI QYALPKSLSV ARLAVNVMGT 1080
LLTVLTQAKR YSFFMPTLPS LVSFCRAFPP LYEDIMSLLI QIGQVCASDV ATQTRDIDPI 1140
ITRLQQIKEK PSGWSQICKD PSYKNGSRDT GSMDPDVQLC HCIESTIIEI INMSVSGI 1198 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |