UniProt Accession

 A8MUT6_HUMAN; A8MUT6 

Genbank Protein ID

 AC068302; AC092937 

Genbank Nucleotide ID

  

Protein Name

 Disks large homolog 1 

Protein Synonyms/Alias

  

Gene Name

 DLG1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
107	SLSPSVEKYRYQDED	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 208 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:Compara.
 GO:0031253; C:cell projection membrane; IEA:Compara.
 GO:0001772; C:immunological synapse; IEA:Compara.
 GO:0043219; C:lateral loop; IEA:Compara.
 GO:0016328; C:lateral plasma membrane; IEA:Compara.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0035748; C:myelin sheath abaxonal region; IEA:Compara.
 GO:0031594; C:neuromuscular junction; IEA:Compara.
 GO:0033268; C:node of Ranvier; IEA:Compara.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0032147; P:activation of protein kinase activity; IEA:Compara.
 GO:0042982; P:amyloid precursor protein metabolic process; IEA:Compara.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Compara.
 GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Compara.
 GO:0060022; P:hard palate development; IEA:Compara.
 GO:0001771; P:immunological synapse formation; IEA:Compara.
 GO:0002088; P:lens development in camera-type eye; IEA:Compara.
 GO:0031579; P:membrane raft organization; IEA:Compara.
 GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Compara.
 GO:0042130; P:negative regulation of T cell proliferation; IEA:Compara.
 GO:0030432; P:peristalsis; IEA:Compara.
 GO:0030838; P:positive regulation of actin filament polymerization; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0008104; P:protein localization; IEA:Compara.
 GO:0042391; P:regulation of membrane potential; IEA:Compara.
 GO:0048608; P:reproductive structure development; IEA:Compara.
 GO:0048745; P:smooth muscle tissue development; IEA:Compara.
 GO:0042110; P:T cell activation; IEA:Compara.
 GO:0002369; P:T cell cytokine production; IEA:Compara. 

Interpro

 IPR004172; L27.
 IPR015143; L27_1.
 IPR019590; MAGUK_PEST_N. 

Pfam

 PF09058; L27_1
 PF10608; MAGUK_N_PEST 

SMART

 SM00569; L27 

PROSITE

 PS51022; L27 

PRINTS