UniProt Accession

 H14_RAT; P15865 

Genbank Protein ID

 X67320; M31229 

Genbank Nucleotide ID

 CAA47734.1; AAA41327.1 

Protein Name

 Histone H1.4 

Protein Synonyms/Alias

 H1d 

Gene Name

 Hist1h1e 

Gene Synonyms/Alias

 H1f4 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
17	AAPAPAEKTPIKKKA	acetylation	[1]
21	PAEKTPIKKKARKAA	acetylation	[1]
117	KAASGEAKPKAKKAG	acetylation	[1]
160	KTPKKAKKPAAAAGA	acetylation	[1]
168	PAAAAGAKKAKSPKK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). 

Sequence Annotation

 DOMAIN 36 109 H15.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 4 4 Phosphothreonine (By similarity).
 MOD_RES 18 18 Phosphothreonine (By similarity).
 MOD_RES 26 26 N6-acetyllysine; alternate (By
 MOD_RES 26 26 N6-methyllysine; alternate (By
 MOD_RES 36 36 Phosphoserine (By similarity).
 MOD_RES 146 146 Phosphothreonine (By similarity).
 MOD_RES 187 187 Phosphoserine (By similarity).  

Keyword

 Acetylation; Chromosome; Complete proteome; Direct protein sequencing; DNA-binding; Methylation; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 219 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; TAS:RGD.
 GO:0000786; C:nucleosome; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0030261; P:chromosome condensation; TAS:RGD.
 GO:0006334; P:nucleosome assembly; IEA:InterPro.
 GO:0016584; P:nucleosome positioning; IEA:Compara. 

Interpro

 IPR005818; Histone_H1/H5.
 IPR005819; Histone_H5.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00538; Linker_histone 

SMART

 SM00526; H15 

PROSITE

 PS51504; H15 

PRINTS

 PR00624; HISTONEH5.