| Tag | Content |
|---|
| CPLM ID | CPLM-004096 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cytochrome P450 2B3 |
Protein Synonyms/Alias | CYPIIB3 |
Gene Name | Cyp2b3 |
Gene Synonyms/Alias | Cyp2b-3 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 239 | REIYKNLKEVLDYID | acetylation | [1] | | 373 | GLPCRITKDTLFRGY | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. |
Sequence Annotation | METAL 436 436 Iron (heme axial ligand). |
Keyword | Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 491 AA |
Protein Sequence | MDTSVLLLLA VLLSFLLFLV RGHAKVHGHL PPGPRPLPLL GNLLQMDRGG FRKSFIQLQE 60
KHGDVFTVYF GPRPVVMLCG TQTIREALVD HAEAFSGRGI IAVLQPIMQE YGVSFVNEER 120
WKILRRLFVA TMRDFGIGKQ SVEDQIKEEA KCLVEELKNH QGVSLDPTFL FQCVTGNIIC 180
SIVFGERFDY RDRQFLRLLD LLYRTFSLIS SFSSQMFEVY SDFLKYFPGV HREIYKNLKE 240
VLDYIDHSVE NHRATLDPNA PRDFIDTFLL HMEKEKLNHY TEFHHWNLMI SVLFLFLAGT 300
ESTSNTLCYG FLLMLKYPHV AEKVQKEIDQ VIGSQRVPTL DDRSKMPYTE AVIHEIQRFS 360
DVSPMGLPCR ITKDTLFRGY LLPKNTEVYF ILSSALHDPQ YFEQPDTFNP EHFLDANGAL 420
KKCEAFMPFS IGKRMCLGEG IARSELFLFF TTILQNYSVS SPVDPNTIDM TPKESGLAKV 480
APVYKICFVA R 491 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD. GO:0070330; F:aromatase activity; IEA:EC. GO:0009055; F:electron carrier activity; IEA:InterPro. GO:0020037; F:heme binding; IEA:InterPro. GO:0005506; F:iron ion binding; IEA:InterPro. GO:0004497; F:monooxygenase activity; TAS:RGD. GO:0042493; P:response to drug; IEP:RGD. GO:0014070; P:response to organic cyclic compound; IEP:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |