UniProt Accession

 ARPC4_MOUSE; P59999; O15509; Q3UWV4 

Genbank Protein ID

 AJ278129; AK017993; AK039215; AK077325; AK133626; AK136082; AK150690; AK153380; AK166440; BC015280 

Genbank Nucleotide ID

 CAC34583.1; BAB31026.1; BAC30279.1; BAC36751.1; BAE21755.1; BAE22810.1; BAE29769.1; BAE31946.1; BAE38777.1 

Protein Name

 Actin-related protein 2/3 complex subunit 4 

Protein Synonyms/Alias

 Arp2/3 complex 20 kDa subunit; p20-ARC 

Gene Name

 Arpc4 

Gene Synonyms/Alias

 Arc20 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
44	EVEVRSSKELLLQPV	acetylation	[1]
44	EVEVRSSKELLLQPV	ubiquitination	[2]
84	KQADEIEKILCHKFM	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylthreonine.  

Keyword

 Acetylation; Actin-binding; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 168 AA 

Protein Sequence

Gene Ontology

 GO:0005885; C:Arp2/3 protein complex; TAS:MGI.
 GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0030041; P:actin filament polymerization; IEA:InterPro.
 GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro. 

Interpro

 IPR008384; ARPC4. 

Pfam

 PF05856; ARPC4 

SMART

  

PROSITE

  

PRINTS