CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027682
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450, family 2, subfamily d, polypeptide 22 
Protein Synonyms/Alias
  
Gene Name
 Cyp2d22 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
96ALREALVKHSEDTADubiquitination[1]
150HHFGLGKKSLEQWVTubiquitination[1]
242RIPGLVGKVFPGKRAubiquitination[1]
262DELLAEHKTTWDPTQubiquitination[1]
286LAEVEKAKGNPESSFubiquitination[1]
380LPLGVPHKTSRDIELubiquitination[1]
407TNLSSALKDETVWEKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 500 AA 
Protein Sequence
MRLPTGAELW PIAIFTVIFL ILVNLMHWRQ RWTAHYPPGP MPWPVLGNLL HMDFQNMPAG 60
FQKLRGRYGD LFSLQLASES VVVLNGLTAL REALVKHSED TADRPPLHFN DLLGFGPRSQ 120
GIVLARYGPA WRQQRRFSVS TMHHFGLGKK SLEQWVTEEA RCLCAAFADH TGHPFSPNTL 180
LDKAVCNVIA SLLYACRFEY DDPRFIRLLG LLKETLKEEA GFLPMFLNVF PMLLRIPGLV 240
GKVFPGKRAF VTMLDELLAE HKTTWDPTQP PRDLTDAFLA EVEKAKGNPE SSFNDENLRT 300
VVGDLFSAGM VTTSTTLSWA LMLMILYPDV QRRVQQEIDE VIGQVQCPEM ADQARMPYTN 360
AVIHEVQRFA DILPLGVPHK TSRDIELQGF LIPKGTTLIT NLSSALKDET VWEKPLCFHP 420
EHFLDAQGHF VKPEAFMPFS AGRRSCLGEP LARMELFLFF TCLLQRFSIS VPDGQPQPSD 480
HGVFRALTTP CPYQLCALPR 500 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I.
 IPR008069; Cyt_P450_E_grp-I_CYP2D-like. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR01686; EP450ICYP2D.
 PR00385; P450.