UniProt Accession

 J3QNL8_MOUSE; J3QNL8 

Genbank Protein ID

 AC132402 

Genbank Nucleotide ID

  

Protein Name

 Pre-mRNA-processing factor 19 

Protein Synonyms/Alias

  

Gene Name

 Prpf19 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
64	VAHPIRPKPPSATSI	ubiquitination	[1]
141	RVIARLTKEVTAARE	ubiquitination	[1]
198	IIQKLQDKATVLTTE	acetylation	[2, 3]
263	ILTGGADKNVVVFDK	acetylation	[3]
263	ILTGGADKNVVVFDK	succinylation	[3]
263	ILTGGADKNVVVFDK	ubiquitination	[1]
270	KNVVVFDKSTEQILA	acetylation	[2]
270	KNVVVFDKSTEQILA	ubiquitination	[1]
280	EQILATLKGHTKKVT	acetylation	[2]
280	EQILATLKGHTKKVT	ubiquitination	[1]
285	TLKGHTKKVTSVVFH	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 523 AA 

Protein Sequence

Gene Ontology

 GO:0005811; C:lipid particle; IDA:MGI.
 GO:0005681; C:spliceosomal complex; ISA:MGI.
 GO:0000151; C:ubiquitin ligase complex; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0001833; P:inner cell mass cell proliferation; IMP:MGI.
 GO:0008610; P:lipid biosynthetic process; IDA:MGI.
 GO:0045665; P:negative regulation of neuron differentiation; IDA:MGI.
 GO:0048711; P:positive regulation of astrocyte differentiation; IDA:MGI.
 GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; IMP:MGI.
 GO:0045666; P:positive regulation of neuron differentiation; ISA:MGI. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR013915; Pre-mRNA_splic_Prp19.
 IPR000772; Ricin_B_lectin.
 IPR003613; Ubox_domain.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF08606; Prp19
 PF04564; U-box
 PF00400; WD40 

SMART

 SM00504; Ubox
 SM00320; WD40 

PROSITE

 PS50231; RICIN_B_LECTIN
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.