| Tag | Content |
|---|
| CPLM ID | CPLM-018551 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Myotubularin-related protein 4 |
Protein Synonyms/Alias | |
Gene Name | Mtmr4 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 257 | YLVTSIAKACALDPG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity). |
Sequence Annotation | DOMAIN 153 570 Myotubularin phosphatase.
ZN_FING 1109 1169 FYVE-type.
REGION 320 323 Substrate binding (By similarity).
REGION 345 346 Substrate binding (By similarity).
REGION 407 413 Substrate binding (By similarity).
ACT_SITE 407 407 Phosphocysteine intermediate (By
BINDING 453 453 Substrate (By similarity).
MOD_RES 637 637 Phosphoserine. |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Hydrolase; Membrane; Metal-binding; Phosphoprotein; Protein phosphatase; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1190 AA |
Protein Sequence | MGEEGPPSLE YIQAKDLFPP KELVKEEENL QVPFTVLQGE GVEFLGRATD ALIAISNYRL 60
HIKFKDSVIN VPLRMIDSVE SRDMFQLHIA CKDSKVVRCH FSTFKQCQEW LSRLSRATAR 120
PAKPEDLFAF AYHAWCLGLT EEDQHTHLCQ PGEHIRCRQE AELARMGFDL QNVWRVSHIN 180
SNYKLCPSYP QKLLVPVWIT DKELENVASF RSWKRIPVVV YRHLRNGAAI ARCSQPEISW 240
WGWRNADDEY LVTSIAKACA LDPGTRASGG SLSTGTNDAS EACDTDFDSS LTACSGVEST 300
AAPQKLLILD ARSYTAAVAN RAKGGGCECE EYYPNCEVLF MGMANIHAIR NSFQYLRAVC 360
SQMPDPSNWL SALESTKWLQ HLSVMLKAAV LVANTVDREG RPVLVHCSDG WDRTPQIVAL 420
AKILLDPYYR TLEGFQVLVE SDWLDFGHKF GDRCGHQENA EDQNEQCPVF LQWLDSVHQL 480
LKQFPCLFEF NEAFLVKLVQ HTYSCLYGTF LANNPCEREK RNIYKRTCSV WALLRAGNKN 540
FHNFLYTPGS DVVLHPVCHV RALHLWTAVY LPASSPCTLG EENMDLYLSP VAQSQEFSGR 600
SLDRLPKTRS MDDLLSACDT SSPLTRTSSD PNLNNHSQEV RGSLEPWHSS PEGAETVIDS 660
GVGSPQLTVG EMGLPPPLPS SQKEYLSNKP FKGHKSCSLS YKLLNTSVSW EMKSNTSDIK 720
VLEETEALAP DPSAQEEQGR TSDGLGKPPE QFLEKEAVSS LCSVSSKCGG ACDFPEPPQD 780
PLTGTPQQPH LDSMQISPSR CTPDHSQGSL CNPPSVASQT PEPNTDLLSQ DPPGSTASIS 840
HQEQPSSVPD LIYKKEDAGK RGSKNGQLLE NPRFGKMPLE LARKPISQSQ ISEFSFLGSN 900
WDSFQGMMTS FPSGETTPRR LLAYGCCSKR PSNKHIRAAG PCLGGQWAQR EGMKSPVCSS 960
HSNGHCTGPG GKNNRMWFSS HPKQVSSTKP SLLSCPSPVP PLYLDDDGLP FPTDVIQHRL 1020
RQIEAGYRQE VEQLRRQVRE LQMRLDIRHC CAPPAEPPMD YEDDFTCLKE SDGSDTEDFG 1080
SDHSEDCLSE ASWEPVDKKE TEVTRWVPDH MASHCFNCDC EFWLAKRRHH CRNCGNVFCA 1140
GCCHLKLPIP DQQLYDPVLV CNSCYEHIQV SRARELMSQH LKKPIATASS 1190 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC. GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |