CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019391
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fatty acyl-CoA reductase 2 
Protein Synonyms/Alias
 Male sterility domain-containing protein 1 
Gene Name
 FAR2 
Gene Synonyms/Alias
 MLSTD1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
29LGKVLMEKLFRTSPDubiquitination[1]
63VFQILDSKLFEKVKEubiquitination[1, 2]
379GRKPRMTKLMNRLLRubiquitination[1, 2]
447GVKKYLLKEDMAGIPubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates. 
Sequence Annotation
  
Keyword
 Complete proteome; Endoplasmic reticulum; Lipid biosynthesis; Lipid metabolism; Membrane; NADP; Oxidoreductase; Peroxisome; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 515 AA 
Protein Sequence
MSTIAAFYGG KSILITGATG FLGKVLMEKL FRTSPDLKVI YILVRPKAGQ TLQQRVFQIL 60
DSKLFEKVKE VCPNVHEKIR AIYADLNQND FAISKEDMQE LLSCTNIIFH CAATVRFDDT 120
LRHAVQLNVT ATRQLLLMAS QMPKLEAFIH ISTAYSNCNL KHIDEVIYPC PVEPKKIIDS 180
LEWLDDAIID EITPKLIRDW PNIYTYTKAL GEMVVQQESR NLNIAIIRPS IVGATWQEPF 240
PGWVDNINGP NGIIIATGKG FLRAIKATPM AVADVIPVDT VVNLMLAVGW YTAVHRPKST 300
LVYHITSGNM NPCNWHKMGV QVLATFEKIP FERPFRRPNA NFTSNSFTSQ YWNAVSHRAP 360
AIIYDCYLRL TGRKPRMTKL MNRLLRTVSM LEYFINRSWE WSTYNTEMLM SELSPEDQRV 420
FNFDVRQLNW LEYIENYVLG VKKYLLKEDM AGIPKAKQRL KRLRNIHYLF NTALFLIAWR 480
LLIARSQMAR NVWFFIVSFC YKFLSYFRAS STLKV 515 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005782; C:peroxisomal matrix; TAS:Reactome.
 GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
 GO:0080019; F:fatty-acyl-CoA reductase (alcohol-forming) activity; IDA:UniProtKB.
 GO:0050062; F:long-chain-fatty-acyl-CoA reductase activity; IEA:Compara.
 GO:0008611; P:ether lipid biosynthetic process; TAS:Reactome.
 GO:0035336; P:long-chain fatty-acyl-CoA metabolic process; IDA:UniProtKB. 
Interpro
 IPR026055; FAR.
 IPR013120; Male_sterile_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF07993; NAD_binding_4
 PF03015; Sterile 
SMART
  
PROSITE
  
PRINTS