UniProt Accession

 CSRP1_HUMAN; P21291 

Genbank Protein ID

 M33146; M76378; M76376; M76377; BC032493 

Genbank Nucleotide ID

 AAA35720.1; AAA58431.1; AAA58431.1; AAA58431.1; AAH32493.1 

Protein Name

 Cysteine and glycine-rich protein 1 

Protein Synonyms/Alias

 Cysteine-rich protein 1; CRP; CRP1 

Gene Name

 CSRP1 

Gene Synonyms/Alias

 CSRP; CYRP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
69	YGKKYGPKGYGYGQG	ubiquitination	[1, 2]
84	AGTLSTDKGESLGIK	ubiquitination	[2]
108	TTNPNASKFAQKIGG	acetylation	[3]
108	TTNPNASKFAQKIGG	ubiquitination	[2]
112	NASKFAQKIGGSERC	acetylation	[3]
131	QAVYAAEKVIGAGKS	acetylation	[3]
173	YCKGCYAKNFGPKGF	ubiquitination	[2]
178	YAKNFGPKGFGFGQG	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Could play a role in neuronal development. 

Sequence Annotation

 DOMAIN 10 61 LIM zinc-binding 1.
 DOMAIN 119 170 LIM zinc-binding 2.
 MOTIF 64 69 Nuclear localization signal (Potential).
 MOD_RES 112 112 N6-acetyllysine.
 MOD_RES 127 127 Phosphotyrosine (By similarity).
 MOD_RES 131 131 N6-acetyllysine.
 MOD_RES 192 192 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; LIM domain; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 193 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008270; F:zinc ion binding; TAS:ProtInc. 

Interpro

 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM 

SMART

 SM00132; LIM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 

PRINTS