CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038562
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Dnah11 
Protein Synonyms/Alias
  
Gene Name
 Dnah11 
Gene Synonyms/Alias
 Dnahc11 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
106IPRDVKHKLVYFAKKacetylation[1]
112HKLVYFAKKMTENMGacetylation[1, 2]
2585DRHKIMLKEIRNCQYacetylation[2]
Reference
 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4488 AA 
Protein Sequence
MAAQEEGTVL RLSPSEQEDE EDEEAAAARR VQRFALDPRV RFLGGRLRQA LRFPEETWGQ 60
YLESDDHRQV LGDFLESTGP ASLVFSVATA GRLSASPEIP RDVKHKLVYF AKKMTENMGE 120
SDFSQTILFG EIPRSLLTHV TAFLDEILVP VLSNKNNHTS WSCFISQDVE HHTEVMKNKM 180
HIFRGKMSRR THLPIPTIAE NIDLDQHYLV TRPQSDERRI LHAIESLVIK WSHQIQEIIE 240
KDSAHPLLSG LHPTPETELD FWTMRHDNLK CIYSQLQAPI VLKMVKILRT RQSSYLPALK 300
GIFTTVENAL LEAQDVELHL RPLRRHIHSL QEAEFPQTRI LIAPLLHTIC LIWSHSKFYN 360
TPARVIVLLQ EFCNLFIDQA RAYLSPEDLL KGEIEDALEK VQVAISVLKT FQNSFFKYRK 420
GLTSYFTRNT EQRSWDFQSH LVFGRFNKFL DRLVKIEDMF VTILEFEKLE RLEFGGSKGA 480
VLNAQIHSTS EEFIECCKVF QQSTYDPSDC DDMEFESDYF KFKSRTLDFD RRLGTLLCEG 540
LSNCSGLESA FKLLTIFGNF LEKPVVMEMF SPHYSTLLNM FNAELDVCKQ LYDEHMKQIE 600
HGHEILNKNM PFTSGNIKWA RMLLERLQMF WSNFTSLHYL FPDSPDEAAV CQKYAEMTTL 660
LDQFESHIYS EWRRNVDETC EFNLNQPLVK FSPINGLLSV NFDPKLVAVL REVKYLLMLK 720
KSDIPDSALG IFQKRNIILK YIGNLELLVQ GYNKLKQTLL EVEYPLIEDE LGAIDEQLRV 780
AATWLTWQDD FWVYMERVQV ATAELECRVS QTQSNMLTIQ QTMQAWAEWP LLPRRETRRE 840
AALTLDDKGD LFAKKYKLIR EDGCKIHNLV EENRKLFRAD PSLDSWKIYV EFIDDIVVEG 900
FFQAILHDLD FFLRNTEKQL KPTPFFQAQM LLMPPEIVFK PPLEKEAGDG FYDLVEEMLC 960
GSFRVSAQMG RVAAHLDIAD YQNDMDNMLG LAEVRQEIMN RVADVINKVL EFRSSLETYS 1020
YLWVDDRVEI LRQFLLYGHA VPSEEMDAPA SEDILQPPTL EQFKEQIDIY EALYIQMSKF 1080
DDFRVFNSWF KVDMRPFKLS LLNVIKKWSW MFQEHLLRFV VDSLSELQGF IKQTNAGLQR 1140
QLCEGDHDGL VDIMGHLLAV RSRQRATDEL FEPLKETIML LESYGQKMPE QVYAQLEELP 1200
ERWETTKKIA AMVRHEVSPL QNAEVTLIRK KCILFDEKQA EFRERFRSYA PLGFKAENPY 1260
AVLDKANQEL EALEEEMEQM QNSARLFEVA LPEYKQMKQC RQEIRLLKGL WDVIIYVRRS 1320
IDNWTETQWR QINVEQMDLE LRRFAKEIWS LDKAVRVWDA YSGLEGTVKD MTTSLRAIAE 1380
LQNPALRDRH WQQLMKAIGV RFSINDSTTL SDLLAVQLHR VEDDVRDIVD QAVKELGTEK 1440
VITDVSHTWE ALEFSYEAHH RTGTPLLKSD EQLFETLEHN QVQLQSLLQS KYVEYFIEQV 1500
LSWQNKLNVA DAVIFTWMQV QRTWSHLESI FVCSEDIRVQ LVEDARRFDK VDAEFKELMF 1560
ETAKVKNVLE ATCRPHLYEK LKDFQHRLSL CEKALAEYLE TKRVTFPRFY FISSADLLDI 1620
LSKGAQPKQV THHLVKLFDS ISDLQFEDNL DVSTHKAVGM FSKEKEYVPF QAGCECIGHV 1680
ESWLLQLEQT MKDTVRLAIT EAITAYEEKP RELWIFDFPA QVALTGSQIW WTTDVGIAFS 1740
RLEEGYETAL KDFHKKQISQ LNTLITLLLG ELSPGDRQKV MTICTIDVHA RDVVAKLISQ 1800
KVVSPHAFTW LSQLRHEWED SRKHCVVNIC DAHFQYFYEY LGNSPRLVIT PLTDRCYITL 1860
TQSLHLTMSG APAGPAGTGK TETTKDLGRA LGMMVYVFNC SEQMDYRSIG NIYKGLVQTG 1920
AWGCFDEFNR IAVEVLSVVA VQVKMIHDAI RNGRKRFVFL GETIPLKPSV GIFITLNPGY 1980
AGRTELPENL KALFRPCAMV APDTELICEI MLVAEGFVDA RSLARKFISL YTLCEELLSK 2040
QDHYDWGLRA IKSVLVVAGS LKRGDKNRPE DQVLMRALRD FNMPKIVTDD VPVFLGLVSD 2100
LFPALDVPRQ RKPHFEQMVK QSTLELRLQP EESFILKVVQ LEELLAVRHS VFVVGNAGTG 2160
KSKILRTLNR TYVNMKQKPV WSDLNPKAVT TDELFGFIHH ATREWKDGLF SSILREQANL 2220
THDGPTWIVL DGDIDPLWIE SLNTVMDDNK VLTLASNERV ALKPSMRLLF ETHHLRTATP 2280
ATVSRAGILY VNPQDLGWNP YVASWIDRRR HQSEKANLTI LFDKYIPVCL EKLRTSFKAI 2340
TSVPESSLVQ TICTLLECLL TPENIPPDSP KETYEVYFAF ACVWTFGGTL LRDQLSDYQA 2400
DFSRWWHKEM KAVKFPSQGT IFDYYLDHKT KKFLPWTDKV PQFSMDADAP LKTVLVHTPE 2460
TTRLRYFTEL LLCKGKPIML VGNAGVGKTV FLSNTLASLS ENYIVSCVPF NYYTTSAALQ 2520
RILEKPLEKK AGRNYGPKGN KKLVYFIDDL NMPEVDLYGT IQPHALLRQH IDYGHWYDRH 2580
KIMLKEIRNC QYVACMNPMV GSFTVNPRLQ RHFTVFAFNF PSLDALTTIY GQIFSFYLQQ 2640
QAFCPSVLRA GPSLIQATIA FHQMMAESFV PTAIKFHYNF NLRDLSNIFQ GILFASPECL 2700
KSLEDLARLW LHETSRVYGD RLIDTNDFDL FQRKMLETAH KYFKGVDANA LLRQPLVYCH 2760
FASGGEDPCY MPVKDWEGLK AVLMEMVDNY NELHSAMHLV LFEDAMQHVC RISRILRIPQ 2820
GHALLIGVGG SGKQSLSRLA AYICSLEVFQ ITLTEGYGAQ ELRVDLANLY VRTGAKNMPT 2880
VFLLTDAHVL DESFLVLIND LLASGDIPDL FSDEDMDKII SGIRNEVRGL GLVDSRENCW 2940
AFFLARVRQQ LKMVFCFSPV GHTLRVRARK FPAIVNCTAI DWFHEWPQEA LVSVSRRFIE 3000
EIEGIEPQHK DSISLFMAHV HTSVKEVSAW YYQNERRYNY TTPRSFLEQI SLFKSLLKKK 3060
REEVKQKQEH LGNGIQKLQT TASQVGNLKS RLASQEAELQ LRNLDAEALI TKIGLQTEKV 3120
SREKAIADAE ERKVAAIQTE ASQKQRECEA DLLKAEPALV AAKDALNTLN RVNLTELKTF 3180
PNPPNAVTNV TAAVMVLLAP RGRVPKDRSW KAAKIFMGKV DDFLQALINY DKEHIPENCL 3240
KVVNEQYLKD PEFNPNLIRT KSFAAAGLCA WVINIIRFYE VYCDVEPKRQ ALAQTNLDLA 3300
AATEKLEAVR RKLVDLDHNL SRLTASFEKA TAEKVRCQEE VNQTNKTIDL ANKLVSELES 3360
EKIRWGQSIK SFETQEKTLC GDVLLTAAFV SYIGSFTRQY RQELVDCKWI PFLQQKVSIP 3420
IAEGLDLIAM LTDDATIATW NNEGLPSDRM STENATILTH CERWPLMIDP QQQGIKWIKN 3480
KYGPDLKVTH LGQKGFLNTI ETALAFGDVI LIENLKETVD PVLGPLLGRN TTKKGKFIRI 3540
GDKECEFNKN FRLILHTKLA NPHYKPELQA QTTLLNFTVT EDGLEGQLLA EVVSIERPDL 3600
ERLKLVLTKQ QNDFKIELRQ LEDDLLLRLS AAEGSFLDDT DLVERLETTK ATAAEIEHKV 3660
TEARENERKI NETRECYRPV AARASLLYFV ISDLRRINPV YQFSLKAFNT LFHRAIEQAD 3720
KVEDTQERIC ALIESITHAT FLYASQALFE RDKLTFLSQM AFQILLRRNE IHPLELDFLL 3780
RFTVEHTYSS PVDFLTAQSW SAVKAVALME EFRGLDRDVE GSAKQWRKWV ESECPEKEKL 3840
PQEWKKKSLI QKLIILRAVR PDRMTYALRN FVEEKLGAKY VERTRLDLGK AFEESSPSTP 3900
VFFILSPGVD ALKDLEVLGK RLGFTIDSGK FHNVSLGQGQ ELVAEMAMEK AAAGGHWVIL 3960
QNVHLVAKWL GTLEKLLEKF SQGSHRDYRV FLSAETVPSQ HEPIIPQGLL ENSIKITNEP 4020
PTGMLANLHA ALYNFDQDTL EMCSKDQEFK SILFSLCYFH ACVAGRLRFG PQGWSRSYPF 4080
SPGDLTICTN ILYNYLEANP NVPWEDLRYL FGEIMYGGHI TDAWDRKLCR VYLEEFMNPS 4140
LIEDEVMLAP GFAAPPYSDY SGYHQYIEDT LPPESPALYG LHPNAEIELL TVTSNTLFRT 4200
LLEMQPRNAV SQEELGQSTE DKVKNILDDI LERLPEEFNM AEIMQKNPNR SPYVLVCFQE 4260
CERMNVLIRE IRVSLQHLDL GLKGELTLSP DVETQLSALS YDRVPDTWNK LAYPSTYGLA 4320
QWFNDLLLRC RELDTWTQDL TLPAVVWLSG FFNPQSFLTA IMQTMARKNE WPLDRMCLTI 4380
DVTKKTKEDY GHPPREGAYL HGLHLEGARW DIQSGALVDA RLKELTSMMP VIFAKAVPVD 4440
RQEIKHAYEC PVYKTKARGP TYVWTFRLRS KDRIAKWVLA GVALLLEA 4488 
Gene Ontology
 GO:0005858; C:axonemal dynein complex; IDA:MGI.
 GO:0005929; C:cilium; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0003777; F:microtubule motor activity; IDA:MGI.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0001539; P:ciliary or flagellar motility; IDA:MGI.
 GO:0007368; P:determination of left/right symmetry; IMP:MGI.
 GO:0007018; P:microtubule-based movement; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR011704; ATPase_dyneun-rel_AAA.
 IPR026983; DHC_fam.
 IPR024743; Dynein_HC_stalk.
 IPR024317; Dynein_heavy_chain_D4_dom.
 IPR004273; Dynein_heavy_dom.
 IPR013594; Dynein_heavy_dom-1.
 IPR013602; Dynein_heavy_dom-2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF07728; AAA_5
 PF12780; AAA_8
 PF08385; DHC_N1
 PF08393; DHC_N2
 PF03028; Dynein_heavy
 PF12777; MT 
SMART
 SM00382; AAA 
PROSITE
  
PRINTS