CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037139
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DNA-dependent protein kinase catalytic subunit 
Protein Synonyms/Alias
  
Gene Name
 PRKDC 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
71GLLVFVRKSLNSIEFubiquitination[1]
99FLEKMGQKIAPYSVEubiquitination[1, 2]
108APYSVEIKNTCTSVYubiquitination[1, 3, 4, 5]
117TCTSVYTKDRAAKCKubiquitination[1, 2, 4, 5, 6]
122YTKDRAAKCKIPALDubiquitination[1]
124KDRAAKCKIPALDLLubiquitination[1]
148SRLMDEFKIGELFSKubiquitination[1, 2, 4, 5, 7]
155KIGELFSKFYGELALubiquitination[1, 2, 4, 7]
163FYGELALKKKIPDTVubiquitination[1, 2, 4, 7]
164YGELALKKKIPDTVLubiquitination[1]
205RAFLGELKTQMTSAVubiquitination[1, 2, 3, 4, 7]
216TSAVREPKLPVLAGCubiquitination[1, 5]
225PVLAGCLKGLSSLLCubiquitination[2]
236SLLCNFTKSMEEDPQubiquitination[1, 4, 5, 6]
254EIFNFVLKAIRPQIDacetylation[8]
254EIFNFVLKAIRPQIDubiquitination[1, 2, 3, 4, 5]
263IRPQIDLKRYAVPSAubiquitination[1, 2, 3, 4, 5, 6, 7]
310HTNVELKKAALSALEubiquitination[1, 2, 3]
329QVSNMVAKNAEMHKNubiquitination[2]
357RNVDSNNKELSIAIRacetylation[8]
357RNVDSNNKELSIAIRubiquitination[1, 2, 3, 4]
374GLFAGPCKVINAKDVubiquitination[1, 4, 5]
379PCKVINAKDVDFMYVubiquitination[1, 2, 4]
393VELIQRCKQMFLTQTubiquitination[1, 4, 5]
471VFLALAAKGPVLRNCubiquitination[1, 3, 4, 5]
493GLIRICSKPVVLPKGubiquitination[1, 4, 5, 6]
499SKPVVLPKGPESESEubiquitination[1, 5]
520EVRTGKWKVPTYKDYubiquitination[1, 5]
525KWKVPTYKDYVDLFRubiquitination[1, 2, 3, 4, 5, 7]
574EFVKSVLKIVEKLDLubiquitination[1, 2]
679ITVRNAKKIKYFEGVubiquitination[1]
681VRNAKKIKYFEGVSPacetylation[9]
681VRNAKKIKYFEGVSPubiquitination[1, 2, 3, 5]
689YFEGVSPKSLKHSPEubiquitination[1, 2, 3, 4, 5, 6, 7]
692GVSPKSLKHSPEDPEubiquitination[1, 2, 4, 5]
700HSPEDPEKYSCFALFubiquitination[1]
712ALFVKFGKEVAVKMKubiquitination[1, 2, 5]
717FGKEVAVKMKQYKDEubiquitination[1]
790HVMQPYYKDILPCLDubiquitination[1, 4]
801PCLDGYLKTSALSDEubiquitination[1, 3, 4, 5]
810SALSDETKNNWEVSAacetylation[8]
810SALSDETKNNWEVSAubiquitination[1, 2, 3, 4, 5, 6, 7]
824ALSRAAQKGFNKVVLubiquitination[1]
828AAQKGFNKVVLKHLKacetylation[8]
828AAQKGFNKVVLKHLKubiquitination[1, 5, 6]
832GFNKVVLKHLKKTKNubiquitination[1, 3, 5]
836VVLKHLKKTKNLSSNubiquitination[1]
838LKHLKKTKNLSSNEAubiquitination[1, 2, 3, 4, 5, 6, 7]
868SLGGQINKNLLTVTSubiquitination[1, 2, 4, 5, 6, 7]
881TSSDEMMKSYVAWDRubiquitination[1, 2, 4, 5, 7]
890YVAWDREKRLSFAVPubiquitination[1]
902AVPFREMKPVIFLDVubiquitination[1, 2]
963PPMYQLYKRTFPVLLubiquitination[1, 2, 3, 4, 6, 7]
1038RCIREFLKWSIKQITubiquitination[1, 3]
1042EFLKWSIKQITPQQQubiquitination[1, 3, 4, 5, 6]
1051ITPQQQEKSPVNTKSubiquitination[1, 2, 5, 6]
1057EKSPVNTKSLFKRLYacetylation[8, 9]
1057EKSPVNTKSLFKRLYubiquitination[1, 2, 4, 5, 6, 7]
1074ALHPNAFKRLGASLAubiquitination[1, 3, 4, 5]
1147KKHVSLNKAKKRRLPubiquitination[4, 6]
1186PQTECRHKSIELFYKubiquitination[1, 2, 4, 5]
1193KSIELFYKFVPLLPGubiquitination[1, 2, 4, 7]
1209RSPNLWLKDVLKEEGacetylation[9]
1209RSPNLWLKDVLKEEGubiquitination[1, 2, 3, 4, 7]
1310HDIIAAEKCFGTGAAubiquitination[2]
1333GERYNYSKCTVVVRIubiquitination[1, 2, 4, 5, 6]
1356NTSPEGWKLLKKDLCubiquitination[1, 2, 4]
1359PEGWKLLKKDLCNTHubiquitination[1]
1360EGWKLLKKDLCNTHLubiquitination[1]
1406VNLMKALKMSPYKDIubiquitination[1, 2, 7]
1411ALKMSPYKDILETHLubiquitination[1, 2, 3, 4, 5]
1421LETHLREKITAQSIEubiquitination[1, 4, 5, 6]
1455AAVVSACKQLHRAGLubiquitination[1, 2, 4, 5, 6]
1488ELLSLVYKGIAPGDEubiquitination[1, 2, 4, 5]
1611FRERANQKHQGLKLAubiquitination[2]
1616NQKHQGLKLATTILQubiquitination[1, 4]
1626TTILQHWKKCDSWWAubiquitination[1, 2, 3]
1627TILQHWKKCDSWWAKubiquitination[1, 5]
1634KCDSWWAKDSPLETKubiquitination[1]
1641KDSPLETKMAVLALLubiquitination[1, 2, 4, 7]
1743NNYVDCMKKFLDALEubiquitination[1, 4, 5, 6]
1744NYVDCMKKFLDALELubiquitination[5]
1806SVYEMFRKDDPRLSFubiquitination[1]
1856VLKSRFTKLNESTFDubiquitination[1, 2, 3, 4, 5, 6, 7]
1868TFDTQITKKMGYYKIubiquitination[1, 2, 3, 4, 5, 6, 7]
1869FDTQITKKMGYYKILubiquitination[1, 5]
1874TKKMGYYKILDVMYSubiquitination[1, 2, 3, 4]
1885VMYSRLPKDDVHAKEubiquitination[1]
1891PKDDVHAKESKINQVubiquitination[1, 2, 4]
1894DVHAKESKINQVFHGubiquitination[1, 4, 5, 6]
1912TEGNELTKTLIKLCYubiquitination[1, 3, 4, 5, 6]
1916ELTKTLIKLCYDAFTubiquitination[4, 5]
1969QGFLFSEKPEKNLLIacetylation[8, 9]
1969QGFLFSEKPEKNLLIubiquitination[1, 2, 3, 5, 6, 7]
1972LFSEKPEKNLLIFENubiquitination[3]
1984FENLIDLKRRYNFPVubiquitination[1, 2, 3, 4, 5, 6, 7]
2001EVPMERKKKYIEIRKubiquitination[1]
2002VPMERKKKYIEIRKEubiquitination[1]
2101APLTALVKHMHRSLGubiquitination[1, 4, 5]
2126RDLPSWMKFLHGKLGubiquitination[1, 3, 4, 5]
2131WMKFLHGKLGNPIVPubiquitination[1, 3, 4, 5]
2226MKHVFHPKRAVFRHNubiquitination[4]
2238RHNLEIIKTLVECWKubiquitination[1]
2245KTLVECWKDCLSIPYubiquitination[1, 4]
2258PYRLIFEKFSGKDPNubiquitination[1, 2, 3, 5]
2262IFEKFSGKDPNSKDNubiquitination[1, 2]
2312NMSFVRYKEVYAAAAubiquitination[1]
2333LRYVMERKNILEESLubiquitination[1, 5, 6]
2346SLCELVAKQLKQHQNubiquitination[1, 2, 4, 5]
2349ELVAKQLKQHQNTMEubiquitination[1, 2, 5]
2358HQNTMEDKFIVCLNKubiquitination[1, 5]
2365KFIVCLNKVTKSFPPubiquitination[1, 5]
2368VCLNKVTKSFPPLADubiquitination[2, 3, 5]
2417LYFQLKSKDFVQVMRubiquitination[1, 2, 4, 5]
2432HRDDERQKVCLDIIYubiquitination[1, 4, 5]
2440VCLDIIYKMMPKLKPubiquitination[1, 4, 5, 6]
2444IIYKMMPKLKPVELRubiquitination[1, 3, 5]
2446YKMMPKLKPVELRELubiquitination[1, 2, 4, 5]
2502QEIFKLAKDVLIQGLubiquitination[1, 2, 7]
2682DSLLFAHKRSERLQRubiquitination[1, 2, 3, 4, 5, 6, 7]
2693RLQRAPLKSVGPDFGubiquitination[1, 2, 3, 5, 6]
2701SVGPDFGKKRLGLPGubiquitination[1, 2, 5]
2702VGPDFGKKRLGLPGDubiquitination[1, 5]
2714PGDEVDNKVKGAAGRubiquitination[1, 2, 4, 5, 6, 7]
2716DEVDNKVKGAAGRTDubiquitination[1, 5, 6]
2737RFMRDQEKLSLMYARacetylation[8]
2737RFMRDQEKLSLMYARubiquitination[1, 3, 5, 6]
2754VAEQKREKEIKSELKubiquitination[1]
2757QKREKEIKSELKMKQubiquitination[1, 5]
2763IKSELKMKQDAQVVLubiquitination[1, 2, 4, 5, 6, 7]
2785DLPDIQIKHSSLITPubiquitination[1, 2, 3, 4, 5, 7]
2805QRDPIIAKQLFSSLFubiquitination[2, 3, 4, 7]
2817SLFSGILKEMDKFKTubiquitination[1]
2823LKEMDKFKTLSEKNNubiquitination[5]
2828KFKTLSEKNNITQKLubiquitination[1, 2, 5]
2834EKNNITQKLLQDFNRubiquitination[1, 2, 3, 4, 7]
2907LPAELPAKRVRGKARubiquitination[1, 2, 3, 4, 5, 6, 7]
2927LRWVELAKLYRSIGEubiquitination[1, 2, 3, 4, 6, 7]
2949FTSEIGTKQITQSALubiquitination[1, 2, 3, 4, 5, 6, 7, 10]
2969SDYSEAAKQYDEALNacetylation[8]
2969SDYSEAAKQYDEALNubiquitination[1, 2, 4, 5, 7]
2977QYDEALNKQDWVDGEubiquitination[2, 7]
3049YMIRSKLKLLLQGEAubiquitination[2]
3066SLLTFIDKAMHGELQubiquitination[1, 2, 7]
3157LSSQVPLKRLLNTWTubiquitination[1, 2, 4, 5, 6, 7]
3171TNRYPDAKMDPMNIWubiquitination[1, 2, 4, 5, 7]
3191NRCFFLSKIEEKLTPubiquitination[1, 2, 3, 4, 5, 6, 7]
3195FLSKIEEKLTPLPEDubiquitination[1, 2, 4, 5, 7]
3234SSLIRSCKFSMKMKMubiquitination[1, 5]
3238RSCKFSMKMKMIDSAubiquitination[1]
3240CKFSMKMKMIDSARKacetylation[5, 9]
3240CKFSMKMKMIDSARKubiquitination[1, 5]
3247KMIDSARKQNNFSLAubiquitination[1, 2, 5, 6]
3256NNFSLAMKLLKELHKubiquitination[1, 3, 4]
3259SLAMKLLKELHKESKacetylation[5, 9]
3259SLAMKLLKELHKESKubiquitination[1, 5]
3263KLLKELHKESKTRDDubiquitination[1, 2]
3301EQVLTVLKTVSLLDEubiquitination[1]
3317NVSSYLSKNILAFRDubiquitination[1, 2, 3, 4, 5, 6, 7]
3354LAEIEEDKARRILELacetylation[5, 8]
3354LAEIEEDKARRILELubiquitination[1, 4, 5, 6]
3371SSSEDSEKVIAGLYQubiquitination[1, 2, 4, 5, 7]
3425FCDQQLRKEEENASVubiquitination[1, 2, 5]
3448YPALVVEKMLKALKLubiquitination[1, 2, 4, 5, 7]
3451LVVEKMLKALKLNSNubiquitination[1]
3454EKMLKALKLNSNEARubiquitination[1, 2, 5, 6, 7]
3549KDTSTGHKNKEFVARubiquitination[1]
3551TSTGHKNKEFVARIKacetylation[5]
3551TSTGHKNKEFVARIKubiquitination[1, 2, 3, 5]
3597DVRAELAKTPVNKKNubiquitination[1, 5]
3607VNKKNIEKMYERMYAacetylation[9]
3607VNKKNIEKMYERMYAubiquitination[1]
3620YAALGDPKAPGLGAFubiquitination[1, 2, 3, 5]
3630GLGAFRRKFIQTFGKubiquitination[1, 5, 6]
3637KFIQTFGKEFDKHFGacetylation[8]
3637KFIQTFGKEFDKHFGubiquitination[1, 3]
3641TFGKEFDKHFGKGGSubiquitination[1, 5]
3645EFDKHFGKGGSKLLRubiquitination[1]
3649HFGKGGSKLLRMKLSubiquitination[1]
3654GSKLLRMKLSDFNDIubiquitination[1, 5, 6]
3668ITNMLLLKMNKDSKPacetylation[8]
3668ITNMLLLKMNKDSKPubiquitination[1, 2, 3, 4, 7]
3671MLLLKMNKDSKPPGNubiquitination[1]
3690SPWMSDFKVEFLRNEacetylation[8]
3690SPWMSDFKVEFLRNEubiquitination[1, 4, 5]
3709GQYDGRGKPLPEYHVubiquitination[1, 2, 3, 4, 5, 6, 7]
3752REHPFLVKGGEDLRQubiquitination[1, 2, 3, 4, 5, 6, 7]
3808RAPPCEYKDWLTKMSubiquitination[1, 3, 4, 5]
3813EYKDWLTKMSGKHDVubiquitination[1, 2, 3, 5, 6, 7]
3817WLTKMSGKHDVGAYMubiquitination[1, 6]
3828GAYMLMYKGANRTETubiquitination[1, 2, 3, 4, 7]
3845SFRKRESKVPADLLKubiquitination[1, 5]
3852KVPADLLKRAFVRMSubiquitination[1, 2, 4, 5, 6, 7]
3975NTMDVFVKEPSFDWKubiquitination[1, 2, 4, 5, 7]
3982KEPSFDWKNFEQKMLubiquitination[1, 4]
3987DWKNFEQKMLKKGGSubiquitination[1, 2]
3991FEQKMLKKGGSWIQEubiquitination[1, 2, 6, 7]
4004QEINVAEKNWYPRQKubiquitination[1, 2, 3, 5, 7]
4011KNWYPRQKICYAKRKubiquitination[1]
4016RQKICYAKRKLAGANubiquitination[1]
4018KICYAKRKLAGANPAubiquitination[1, 5, 6]
4038ELLLGHEKAPAFRDYubiquitination[1, 4, 5, 6]
4073LSEETQVKCLMDQATubiquitination[1, 4, 6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [8] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [9] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [10] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4096 AA 
Protein Sequence
MAGSGAGVRC SLLRLQETLS AADRCGAALA GHQLIRGLGQ ECVLSSSPAV LALQTSLVFS 60
RDFGLLVFVR KSLNSIEFRE CREEILKFLC IFLEKMGQKI APYSVEIKNT CTSVYTKDRA 120
AKCKIPALDL LIKLLQTFRS SRLMDEFKIG ELFSKFYGEL ALKKKIPDTV LEKVYELLGL 180
LGEVHPSEMI NNAENLFRAF LGELKTQMTS AVREPKLPVL AGCLKGLSSL LCNFTKSMEE 240
DPQTSREIFN FVLKAIRPQI DLKRYAVPSA GLRLFALHAS QFSTCLLDNY VSLFEVLLKW 300
CAHTNVELKK AALSALESFL KQVSNMVAKN AEMHKNKLQY FMEQFYGIIR NVDSNNKELS 360
IAIRGYGLFA GPCKVINAKD VDFMYVELIQ RCKQMFLTQT DTGDDRVYQM PSFLQSVASV 420
LLYLDTVPEV YTPVLEHLVV MQIDSFPQYS PKMQLVCCRA IVKVFLALAA KGPVLRNCIS 480
TVVHQGLIRI CSKPVVLPKG PESESEDHRA SGEVRTGKWK VPTYKDYVDL FRHLLSSDQM 540
MDSILADEAF FSVNSSSESL NHLLYDEFVK SVLKIVEKLD LTLEIQTVGE QENGDEAPGV 600
WMIPTSDPAA NLHPAKPKDF SAFINLVEFC REILPEKQAE FFEPWVYSFS YELILQSTRL 660
PLISGFYKLL SITVRNAKKI KYFEGVSPKS LKHSPEDPEK YSCFALFVKF GKEVAVKMKQ 720
YKDELLASCL TFLLSLPHNI IELDVRAYVP ALQMAFKLGL SYTPLAEVGL NALEEWSIYI 780
DRHVMQPYYK DILPCLDGYL KTSALSDETK NNWEVSALSR AAQKGFNKVV LKHLKKTKNL 840
SSNEAISLEE IRIRVVQMLG SLGGQINKNL LTVTSSDEMM KSYVAWDREK RLSFAVPFRE 900
MKPVIFLDVF LPRVTELALT ASDRQTKVAA CELLHSMVMF MLGKATQMPE GGQGAPPMYQ 960
LYKRTFPVLL RLACDVDQVT RQLYEPLVMQ LIHWFTNNKK FESQDTVALL EAILDGIVDP 1020
VDSTLRDFCG RCIREFLKWS IKQITPQQQE KSPVNTKSLF KRLYSLALHP NAFKRLGASL 1080
AFNNIYREFR EEESLVEQFV FEALVIYMES LALAHADEKS LGTIQQCCDA IDHLCRIIEK 1140
KHVSLNKAKK RRLPRGFPPS ASLCLLDLVK WLLAHCGRPQ TECRHKSIEL FYKFVPLLPG 1200
NRSPNLWLKD VLKEEGVSFL INTFEGGGCG QPSGILAQPT LLYRGPFSLQ ATLCWLDLLL 1260
AALECYNTFI GERTVGALQV LGTEAQSSLL KAVAFFLESI AMHDIIAAEK CFGTGAAGNR 1320
TSPQEGERYN YSKCTVVVRI MEFTTTLLNT SPEGWKLLKK DLCNTHLMRV LVQTLCEPAS 1380
IGFNIGDVQV MAHLPDVCVN LMKALKMSPY KDILETHLRE KITAQSIEEL CAVNLYGPDA 1440
QVDRSRLAAV VSACKQLHRA GLLHNILPSQ STDLHHSVGT ELLSLVYKGI APGDERQCLP 1500
SLDLSCKQLA SGLLELAFAF GGLCERLVSL LLNPAVLSTA SLGSSQGSVI HFSHGEYFYS 1560
LFSETINTEL LKNLDLAVLE LMQSSVDNTK MVSAVLNGML DQSFRERANQ KHQGLKLATT 1620
ILQHWKKCDS WWAKDSPLET KMAVLALLAK ILQIDSSVSF NTSHGSFPEV FTTYISLLAD 1680
TKLDLHLKGQ AVTLLPFFTS LTGGSLEELR RVLEQLIVAH FPMQSREFPP GTPRFNNYVD 1740
CMKKFLDALE LSQSPMLLEL MTEVLCREQQ HVMEELFQSS FRRIARRGSC VTQVGLLESV 1800
YEMFRKDDPR LSFTRQSFVD RSLLTLLWHC SLDALREFFS TIVVDAIDVL KSRFTKLNES 1860
TFDTQITKKM GYYKILDVMY SRLPKDDVHA KESKINQVFH GSCITEGNEL TKTLIKLCYD 1920
AFTENMAGEN QLLERRRLYH CAAYNCAISV ICCVFNELKF YQGFLFSEKP EKNLLIFENL 1980
IDLKRRYNFP VEVEVPMERK KKYIEIRKEA REAANGDSDG PSYMSSLSYL ADSTLSEEMS 2040
QFDFSTGVQS YSYSSQDPRP ATGRFRRREQ RDPTVHDDVL ELEMDELNRH ECMAPLTALV 2100
KHMHRSLGPP QGEEDSVPRD LPSWMKFLHG KLGNPIVPLN IRLFLAKLVI NTEEVFRPYA 2160
KHWLSPLLQL AASENNGGEG IHYMVVEIVA TILSWTGLAT PTGVPKDEVL ANRLLNFLMK 2220
HVFHPKRAVF RHNLEIIKTL VECWKDCLSI PYRLIFEKFS GKDPNSKDNS VGIQLLGIVM 2280
ANDLPPYDPQ CGIQSSEYFQ ALVNNMSFVR YKEVYAAAAE VLGLILRYVM ERKNILEESL 2340
CELVAKQLKQ HQNTMEDKFI VCLNKVTKSF PPLADRFMNA VFFLLPKFHG VLKTLCLEVV 2400
LCRVEGMTEL YFQLKSKDFV QVMRHRDDER QKVCLDIIYK MMPKLKPVEL RELLNPVVEF 2460
VSHPSTTCRE QMYNILMWIH DNYRDPESET DNDSQEIFKL AKDVLIQGLI DENPGLQLII 2520
RNFWSHETRL PSNTLDRLLA LNSLYSPKIE VHFLSLATNF LLEMTSMSPD YPNPMFEHPL 2580
SECEFQEYTI DSDWRFRSTV LTPMFVETQA SQGTLQTRTQ EGSLSARWPV AGQIRATQQQ 2640
HDFTLTQTAD GRSSFDWLTG SSTDPLVDHT SPSSDSLLFA HKRSERLQRA PLKSVGPDFG 2700
KKRLGLPGDE VDNKVKGAAG RTDLLRLRRR FMRDQEKLSL MYARKGVAEQ KREKEIKSEL 2760
KMKQDAQVVL YRSYRHGDLP DIQIKHSSLI TPLQAVAQRD PIIAKQLFSS LFSGILKEMD 2820
KFKTLSEKNN ITQKLLQDFN RFLNTTFSFF PPFVSCIQDI SCQHAALLSL DPAAVSAGCL 2880
ASLQQPVGIR LLEEALLRLL PAELPAKRVR GKARLPPDVL RWVELAKLYR SIGEYDVLRG 2940
IFTSEIGTKQ ITQSALLAEA RSDYSEAAKQ YDEALNKQDW VDGEPTEAEK DFWELASLDC 3000
YNHLAEWKSL EYCSTASIDS ENPPDLNKIW SEPFYQETYL PYMIRSKLKL LLQGEADQSL 3060
LTFIDKAMHG ELQKAILELH YSQELSLLYL LQDDVDRAKY YIQNGIQSFM QNYSSIDVLL 3120
HQSRLTKLQS VQALTEIQEF ISFISKQGNL SSQVPLKRLL NTWTNRYPDA KMDPMNIWDD 3180
IITNRCFFLS KIEEKLTPLP EDNSMNVDQD GDPSDRMEVQ EQEEDISSLI RSCKFSMKMK 3240
MIDSARKQNN FSLAMKLLKE LHKESKTRDD WLVSWVQSYC RLSHCRSRSQ GCSEQVLTVL 3300
KTVSLLDENN VSSYLSKNIL AFRDQNILLG TTYRIIANAL SSEPACLAEI EEDKARRILE 3360
LSGSSSEDSE KVIAGLYQRA FQHLSEAVQA AEEEAQPPSW SCGPAAGVID AYMTLADFCD 3420
QQLRKEEENA SVIDSAELQA YPALVVEKML KALKLNSNEA RLKFPRLLQI IERYPEETLS 3480
LMTKEISSVP CWQFISWISH MVALLDKDQA VAVQHSVEEI TDNYPQAIVY PFIISSESYS 3540
FKDTSTGHKN KEFVARIKSK LDQGGVIQDF INALDQLSNP ELLFKDWSND VRAELAKTPV 3600
NKKNIEKMYE RMYAALGDPK APGLGAFRRK FIQTFGKEFD KHFGKGGSKL LRMKLSDFND 3660
ITNMLLLKMN KDSKPPGNLK ECSPWMSDFK VEFLRNELEI PGQYDGRGKP LPEYHVRIAG 3720
FDERVTVMAS LRRPKRIIIR GHDEREHPFL VKGGEDLRQD QRVEQLFQVM NGILAQDSAC 3780
SQRALQLRTY SVVPMTSSDP RAPPCEYKDW LTKMSGKHDV GAYMLMYKGA NRTETVTSFR 3840
KRESKVPADL LKRAFVRMST SPEAFLALRS HFASSHALIC ISHWILGIGD RHLNNFMVAM 3900
ETGGVIGIDF GHAFGSATQF LPVPELMPFR LTRQFINLML PMKETGLMYS IMVHALRAFR 3960
SDPGLLTNTM DVFVKEPSFD WKNFEQKMLK KGGSWIQEIN VAEKNWYPRQ KICYAKRKLA 4020
GANPAVITCD ELLLGHEKAP AFRDYVAVAR GSKDHNIRAQ EPESGLSEET QVKCLMDQAT 4080
DPNILGRTWE GWEPWM 4096 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
 GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR003152; FATC.
 IPR011009; Kinase-like_dom.
 IPR012582; NUC194.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR018936; PI3/4_kinase_CS.
 IPR003151; PIK-rel_kinase_FAT.
 IPR014009; PIK_FAT. 
Pfam
 PF02259; FAT
 PF02260; FATC
 PF08163; NUC194
 PF00454; PI3_PI4_kinase 
SMART
 SM00146; PI3Kc 
PROSITE
 PS51189; FAT
 PS51190; FATC
 PS00915; PI3_4_KINASE_1
 PS00916; PI3_4_KINASE_2
 PS50290; PI3_4_KINASE_3 
PRINTS