CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017913
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc transporter 5 
Protein Synonyms/Alias
 ZnT-5; Solute carrier family 30 member 5; ZnT-like transporter 1; hZTL1 
Gene Name
 SLC30A5 
Gene Synonyms/Alias
 ZNT5; ZNTL1; ZTL1; UNQ863/PRO1879 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
371SPSKRGQKGTLIGYSubiquitination[1]
759MESMKYCKDGTYIM*ubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP. 
Sequence Annotation
 REGION 542 578 His-rich loop.  
Keyword
 Alternative splicing; Complete proteome; Golgi apparatus; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 765 AA 
Protein Sequence
MEEKYGGDVL AGPGGGGGLG PVDVPSARLT KYIVLLCFTK FLKAVGLFES YDLLKAVHIV 60
QFIFILKLGT AFFMVLFQKP FSSGKTITKH QWIKIFKHAV AGCIISLLWF FGLTLCGPLR 120
TLLLFEHSDI VVISLLSVLF TSSGGGPAKT RGAAFFIIAV ICLLLFDNDD LMAKMAEHPE 180
GHHDSALTHM LYTAIAFLGV ADHKGGVLLL VLALCCKVGF HTASRKLSVD VGGAKRLQAL 240
SHLVSVLLLC PWVIVLSVTT ESKVESWFSL IMPFATVIFF VMILDFYVDS ICSVKMEVSK 300
CARYGSFPIF ISALLFGNFW THPITDQLRA MNKAAHQEST EHVLSGGVVV SAIFFILSAN 360
ILSSPSKRGQ KGTLIGYSPE GTPLYNFMGD AFQHSSQSIP RFIKESLKQI LEESDSRQIF 420
YFLCLNLLFT FVELFYGVLT NSLGLISDGF HMLFDCSALV MGLFAALMSR WKATRIFSYG 480
YGRIEILSGF INGLFLIVIA FFVFMESVAR LIDPPELDTH MLTPVSVGGL IVNLIGICAF 540
SHAHSHAHGA SQGSCHSSDH SHSHHMHGHS DHGHGHSHGS AGGGMNANMR GVFLHVLADT 600
LGSIGVIVST VLIEQFGWFI ADPLCSLFIA ILIFLSVVPL IKDACQVLLL RLPPEYEKEL 660
HIALEKIQKI EGLISYRDPH FWRHSASIVA GTIHIQVTSD VLEQRIVQQV TGILKDAGVN 720
NLTIQVEKEA YFQHMSGLST GFHDVLAMTK QMESMKYCKD GTYIM 765 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; TAS:UniProtKB.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0030667; C:secretory granule membrane; TAS:Reactome.
 GO:0008270; F:zinc ion binding; NAS:UniProtKB.
 GO:0005385; F:zinc ion transmembrane transporter activity; IDA:UniProtKB.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0006882; P:cellular zinc ion homeostasis; IDA:UniProtKB.
 GO:0006824; P:cobalt ion transport; IDA:MGI.
 GO:0010155; P:regulation of proton transport; NAS:UniProtKB.
 GO:0010043; P:response to zinc ion; IDA:UniProtKB. 
Interpro
 IPR002524; Cation_efflux.
 IPR027469; Cation_efflux_TMD. 
Pfam
 PF01545; Cation_efflux 
SMART
  
PROSITE
  
PRINTS