CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002191
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Anion exchange protein 2 
Protein Synonyms/Alias
 AE 2; Anion exchanger 2; Non-erythroid band 3-like protein; BND3L; Solute carrier family 4 member 2 
Gene Name
 SLC4A2 
Gene Synonyms/Alias
 AE2; EPB3L1; HKB3; MPB3L 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
188EATPRASKGAQAGTQubiquitination[1]
653TGAGLEPKSAQDKALubiquitination[1, 2]
658EPKSAQDKALLQMVEubiquitination[1, 2, 3]
893AGQSGQGKPRGQPNTubiquitination[1, 2]
975FSVTAPEKRGWVINPubiquitination[1, 2]
1073NALTVMSKAVAPGDKubiquitination[1]
1087KPKIQEVKEQRVTGLubiquitination[1]
1156HPDVTYVKKVRTLRMubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 
Functional Description
 Plasma membrane anion exchange protein of wide distribution. 
Sequence Annotation
 REGION 708 1241 Membrane (anion exchange).
 MOD_RES 113 113 Phosphoserine.
 MOD_RES 132 132 Phosphoserine.
 MOD_RES 144 144 Phosphoserine.
 MOD_RES 173 173 Phosphoserine.
 MOD_RES 183 183 Phosphothreonine.
 MOD_RES 443 443 Phosphoserine.
 LIPID 1173 1173 S-palmitoyl cysteine (By similarity).
 CARBOHYD 859 859 N-linked (GlcNAc...) (Potential).
 CARBOHYD 868 868 N-linked (GlcNAc...) (Potential).
 CARBOHYD 882 882 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Anion exchange; Antiport; Complete proteome; Glycoprotein; Ion transport; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1241 AA 
Protein Sequence
MSSAPRRPAK GADSFCTPEP ESLGPGTPGF PEQEEDELHR TLGVERFEEI LQEAGSRGGE 60
EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ GPGRKPRRRP GASPTGETPT 120
IEEGEEDEDE ASEAEGARAL TQPSPVSTPS SVQFFLQEDD SADRKAERTS PSSPAPLPHQ 180
EATPRASKGA QAGTQVEEAE AEAVAVASGT AGGDDGGASG RPLPKAQPGH RSYNLQERRR 240
IGSMTGAEQA LLPRVPTDEI EAQTLATADL DLMKSHRFED VPGVRRHLVR KNAKGSTQSG 300
REGREPGPTP RARPRAPHKP HEVFVELNEL LLDKNQEPQW RETARWIKFE EDVEEETERW 360
GKPHVASLSF RSLLELRRTL AHGAVLLDLD QQTLPGVAHQ VVEQMVISDQ IKAEDRANVL 420
RALLLKHSHP SDEKDFSFPR NISAGSLGSL LGHHHGQGAE SDPHVTEPLM GGVPETRLEV 480
ERERELPPPA PPAGITRSKS KHELKLLEKI PENAEATVVL VGCVEFLSRP TMAFVRLREA 540
VELDAVLEVP VPVRFLFLLL GPSSANMDYH EIGRSISTLM SDKQFHEAAY LADEREDLLT 600
AINAFLDCSV VLPPSEVQGE ELLRSVAHFQ RQMLKKREEQ GRLLPTGAGL EPKSAQDKAL 660
LQMVEAAGAA EDDPLRRTGR PFGGLIRDVR RRYPHYLSDF RDALDPQCLA AVIFIYFAAL 720
SPAITFGGLL GEKTQDLIGV SELIMSTALQ GVVFCLLGAQ PLLVIGFSGP LLVFEEAFFS 780
FCSSNHLEYL VGRVWIGFWL VFLALLMVAL EGSFLVRFVS RFTQEIFAFL ISLIFIYETF 840
YKLVKIFQEH PLHGCSASNS SEVDGGENMT WAGARPTLGP GNRSLAGQSG QGKPRGQPNT 900
ALLSLVLMAG TFFIAFFLRK FKNSRFFPGR IRRVIGDFGV PIAILIMVLV DYSIEDTYTQ 960
KLSVPSGFSV TAPEKRGWVI NPLGEKSPFP VWMMVASLLP AILVFILIFM ETQITTLIIS 1020
KKERMLQKGS GFHLDLLLIV AMGGICALFG LPWLAAATVR SVTHANALTV MSKAVAPGDK 1080
PKIQEVKEQR VTGLLVALLV GLSIVIGDLL RQIPLAVLFG IFLYMGVTSL NGIQFYERLH 1140
LLLMPPKHHP DVTYVKKVRT LRMHLFTALQ LLCLALLWAV MSTAASLAFP FILILTVPLR 1200
MVVLTRIFTD REMKCLDANE AEPVFDEREG VDEYNEMPMP V 1241 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0008509; F:anion transmembrane transporter activity; TAS:ProtInc.
 GO:0015108; F:chloride transmembrane transporter activity; IEA:Compara.
 GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro.
 GO:0015701; P:bicarbonate transport; TAS:Reactome. 
Interpro
 IPR001717; Anion_exchange.
 IPR002978; Anion_exchange_2.
 IPR018241; Anion_exchange_CS.
 IPR013769; Band3_cytoplasmic_dom.
 IPR011531; HCO3_transpt_C.
 IPR003020; HCO3_transpt_euk.
 IPR016152; PTrfase/Anion_transptr. 
Pfam
 PF07565; Band_3_cyto
 PF00955; HCO3_cotransp 
SMART
  
PROSITE
 PS00219; ANION_EXCHANGER_1
 PS00220; ANION_EXCHANGER_2 
PRINTS
 PR00165; ANIONEXCHNGR.
 PR01188; ANIONEXHNGR2.
 PR01231; HCO3TRNSPORT.