UniProt Accession

 TYB10_MOUSE; Q6ZWY8; Q3V2M3 

Genbank Protein ID

 AK003178; AK005512; AK008557; AK012361; AK019212; AK019232; AK131711; AK161987 

Genbank Nucleotide ID

 BAB22622.1; BAB24091.1; BAB25742.1; BAB28189.1; BAB31603.1; BAB31614.1; BAE20774.1; BAE36668.1 

Protein Name

 Thymosin beta-10 

Protein Synonyms/Alias

  

Gene Name

 Tmsb10 

Gene Synonyms/Alias

 Ptmb10 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
4	****MADKPDMGEIA	acetylation	[1, 2]
15	GEIASFDKAKLKKTE	acetylation	[1, 2]
26	KKTETQEKNTLPTKE	acetylation	[2]
32	EKNTLPTKETIEQEK	ubiquitination	[3]

Reference

 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 4 4 N6-acetyllysine (By similarity).
 MOD_RES 15 15 N6-acetyllysine (By similarity).
 MOD_RES 23 23 Phosphothreonine (By similarity).
 MOD_RES 39 39 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 44 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
 GO:0042989; P:sequestering of actin monomers; IEA:InterPro. 

Interpro

 IPR001152; Thymosin_b4.
 IPR016323; Thymosin_b4_chordata. 

Pfam

 PF01290; Thymosin 

SMART

 SM00152; THY 

PROSITE

 PS00500; THYMOSIN_B4 

PRINTS