CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038393
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Spectrin beta chain, erythrocytic 
Protein Synonyms/Alias
  
Gene Name
 Sptb 
Gene Synonyms/Alias
 Spnb1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
57DEREVVQKKTFTKWVubiquitination[1]
80CRISDLYKDLRDGRMubiquitination[1]
105EMLPRPTKGKMRIHCubiquitination[1]
118HCLENVDKALQFLKEacetylation[2]
118HCLENVDKALQFLKEubiquitination[1]
224PDLIDFDKLKDSNARacetylation[2]
461LAAVEAAKKKHEAIEubiquitination[1]
585AIQGDKVKAITAATLubiquitination[1]
598TLQFAEGKGYQPCDPubiquitination[1]
1175LGFQEFQKDAKQAEAubiquitination[1]
1670RLQGQVDKQYAGLKDubiquitination[1]
1957AEINTRAKNFSTCLEubiquitination[1]
2070ERFAALEKPTTLELKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2137 AA 
Protein Sequence
MTSATEFENV GNQPPFSRIN ARWDAPDDEL DNDNSSARLF ERSRIKALAD EREVVQKKTF 60
TKWVNSHLAR VSCRISDLYK DLRDGRMLIK LLEVLSGEML PRPTKGKMRI HCLENVDKAL 120
QFLKEQRVHL ENMGSHDIVD GNHRLVLGLI WTIILRFQIQ DIVVQTQEGR ETRSAKDALL 180
LWCQMKTAGY PHVNVTNFTS SWKDGLAFNA LIHKHRPDLI DFDKLKDSNA RHNLEHAFDV 240
AERQLGIIPL LDPEDVFTEN PDEKSIITYV VAFYHYFSKM KVLAVEGKRV GKVIDHAIET 300
EKMIEKYSGL ASDLLTWIEQ TISVLNSRKF ANSLSGVQQQ LQAFSTYRTV EKPPKFQEKG 360
NLEVLLFTIQ SRMRANNQKV YTPHDGKLVS DINRAWESLE EAEYQRELAL RSELIRQEKL 420
EQLARRFDRK AAMRETWLNE NQRLVTQDNF GYDLAAVEAA KKKHEAIETD TAAYEERVKA 480
LEDLAQELEK ENYHDQKRII ARKDNILRLW SYLQELLRSR RQRLEATLAL QKLFQDMLHS 540
IDWMDEIKAH ILSAEFGKHL LEVEDLLQKH KLMEADIAIQ GDKVKAITAA TLQFAEGKGY 600
QPCDPQVIQD RVSHLEQCFS ELSNMAAGRK AQLEQSKRLW KFFWEMDEAE SWIKEKEQIY 660
SSLDYGKDLT SVLILQRKHK AFEDELRGLD AHLKQIFQEA DDMVAQKQFG HPQIETRVKE 720
VSAQWDHLKE LAAFRKKDLQ DAENFFQFQG DADDLKAWLQ DAHRLLSGED VGQDEGATRA 780
LGKKHKEFLE ELEESRGVME HLEHQAQGFP EEFRDSPDVT NRLQALRKLY QQVLTQAELR 840
GHKLQEALDL YTVFGESDAC ELWMTEKGKW LDQMDIPNTL EDLEVVQHRF DILDQEMKTL 900
MAQIDGVNLA ANNLVESGHP RSGEVKQYQD RLNKRWQAFQ AVVSEQREAV DSALRVNNYC 960
VDCEETSKWI MDKTKVVEST KDLGQDLAGV IAIQRKLSGL ERDVLAIRDR VSALERESQY 1020
LMESHPEQKE DIGQRQADVE KLWKGLQDAL QGQELSLGEA SKLQAFLQDL DDFKAWLSMA 1080
QKAVASEDMP ESLPEAEQLL QQHAAIKEEI DAHRDDYHRV KASGEKVIEG QTDPDYQLLG 1140
QRLEGLDTDW DALRRMWESR GNTLTQCLGF QEFQKDAKQA EAILSNQEYT LAHLEPPDSL 1200
AAAEAGIRKF EDFLVSMENN RDKILSPVDS GNKLVAEGNL YSNKIMEKVQ LIEDRHKKNN 1260
EKAQEATVLL KDNLELQNFL QNCKELTLWI NDKLLTSPDV SYDEARNLHN KWMKHQAFMA 1320
ELASHQGWLE NIDAEGRQLM AEKPQFKDVV SERLEALHKL WEELQSTAKA KAEQLSAARS 1380
SDLRLQTHAD LNKWIGAMED QLRSDDLGKD LTTVNRMLAK LKALEEQVNL RKEELEELFA 1440
DAPSLGAEAG DTDMSIEKRF LDLLEPLGRR KKQLELSKAK LQISRDLEDE TLWVEERLPL 1500
AQSADYGTNL QTVQLFMKKN QTLQNEILGH APRVEDVLRR GQELVKAAEI DCQDIEERLG 1560
HLQSSWDTLR EAAAGRLQRL RDAHEAQQYY LDAGEAEAWI SEQELYVFSD EPPKDEEGAI 1620
VMLKRHLRQQ RTVEEYGRNI KQLAGRAQSL LSAGHPEGEQ IIRLQGQVDK QYAGLKDMAE 1680
ERRRRLENMY HLFQLKREAD DLEQWITEKE MVASSQEMGQ DFDHVTMLRD KFRDFARETG 1740
AIGQERVDNV NTIIERLIDA GHSEAATIAE WKDGLNDMWA DLLELIDTRM QLLAASYDLH 1800
RYFYTGTEIL GLIDEKHREL PEDVGLDAST AESFHRVHTA FERELHLLGV QVQQFQDVAT 1860
RLQTAYAGEK ADAIQSKEQE VSAAWQALLD ACAGRRAQLV DTADKFRFFS MVRDLLSWME 1920
SIIRQIETQE RPRDVSSVEL LLKYHQGIKA EINTRAKNFS TCLELGESLL QRQHQASDEI 1980
REKLQQVISR RQEMNDKWEA RSDRLHMLLE VCQFSRDASV AEAWLIAQEP YLASRDFGHT 2040
VDSVEKLIKR HEAFEKSTAS WAERFAALEK PTTLELKERQ TPERPTEEPG PQEEEGETAG 2100
EAPQVHHAAT ERTSPVSFMS RLSSSWESLL PEPAHPF 2137 
Gene Ontology
 GO:0030863; C:cortical cytoskeleton; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0008091; C:spectrin; IEA:InterPro.
 GO:0014731; C:spectrin-associated cytoskeleton; IMP:MGI.
 GO:0051015; F:actin filament binding; IDA:MGI.
 GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
 GO:0030097; P:hemopoiesis; IMP:MGI.
 GO:0007009; P:plasma membrane organization; IMP:MGI.
 GO:0006779; P:porphyrin-containing compound biosynthetic process; IMP:MGI. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR018159; Spectrin/alpha-actinin.
 IPR016343; Spectrin_bsu.
 IPR002017; Spectrin_repeat. 
Pfam
 PF00307; CH
 PF00435; Spectrin 
SMART
 SM00033; CH
 SM00150; SPEC 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH 
PRINTS