UniProt Accession

 H4_LITVA; P83865 

Genbank Protein ID

  

Genbank Nucleotide ID

  

Protein Name

 Histone H4 

Protein Synonyms/Alias

  

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei) 

NCBI Taxa ID

 6689 

Lysine Modification

Position	Peptide	Type	References
6	**MTGRGKGGKGLGK	acetylation	[1]
9	TGRGKGGKGLGKGGA	acetylation	[1]
13	KGGKGLGKGGAKRHR	acetylation	[1]
17	GLGKGGAKRHRKVLR	acetylation	[1]
32	DNIQGITKPAIRRLA	methylation	[2]

Reference

 [1] Characterization of antimicrobial histone sequences and posttranslational modifications by mass spectrometry.
 Ouvry-Patat SA, Schey KL.
 J Mass Spectrom. 2007 May;42(5):664-74. [PMID: 17405180]
 [2] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 2 2 N-acetylthreonine.
 MOD_RES 6 6 N6-acetyllysine.
 MOD_RES 9 9 N6-acetyllysine.
 MOD_RES 13 13 N6-acetyllysine.
 MOD_RES 17 17 N6-acetyllysine.
 MOD_RES 21 21 N6,N6-dimethyllysine.
 MOD_RES 32 32 N6-methyllysine.  

Keyword

 Acetylation; Antibiotic; Antimicrobial; Chromosome; Direct protein sequencing; DNA-binding; Methylation; Nucleosome core; Nucleus. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 103 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; ISS:UniProtKB.
 GO:0042742; P:defense response to bacterium; IDA:UniProtKB.
 GO:0006334; P:nucleosome assembly; ISS:UniProtKB. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR001951; Histone_H4.
 IPR019809; Histone_H4_CS. 

Pfam

 PF00125; Histone 

SMART

 SM00417; H4 

PROSITE

 PS00047; HISTONE_H4 

PRINTS

 PR00623; HISTONEH4.