UniProt Accession

 PA2G4_MOUSE; P50580 

Genbank Protein ID

 X84789; U43918; BC046532 

Genbank Nucleotide ID

 CAA59260.1; AAB60513.1; AAH46532.1 

Protein Name

 Proliferation-associated protein 2G4 

Protein Synonyms/Alias

 IRES-specific cellular trans-acting factor 45 kDa; ITAF45; Mpp1; Proliferation-associated protein 1; Protein p38-2G4 

Gene Name

 Pa2g4 

Gene Synonyms/Alias

 Ebp1; Plfap 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
22	DLVVTKYKMGGDIAN	ubiquitination	[1]
158	EAALRLVKPGNQNTQ	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly (By similarity). Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Together with PTBP1 is required for the translation initiation on the foot- and-mouth disease virus (FMDV) IRES. 

Sequence Annotation

 REGION 2 48 Necessary for nucleolar localization (By
 REGION 46 54 RNA-binding (By similarity).
 REGION 301 394 Necessary for nucleolar localization (By
 REGION 361 375 Interaction with RNA.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine.
 MOD_RES 361 361 Phosphoserine (By similarity).
 MOD_RES 386 386 Phosphothreonine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repressor; Ribonucleoprotein; RNA-binding; rRNA processing; Transcription; Transcription regulation; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 394 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; ISA:MGI.
 GO:0030529; C:ribonucleoprotein complex; ISO:MGI.
 GO:0003677; F:DNA binding; ISA:MGI.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISA:MGI.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISA:MGI.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR004545; Pap_1.
 IPR000994; Pept_M24_structural-domain.
 IPR018349; Pept_M24A_MAP2_BS.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00557; Peptidase_M24 

SMART

  

PROSITE

 PS01202; MAP_2 

PRINTS