CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022755
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adenylate kinase isoenzyme 1 
Protein Synonyms/Alias
 AK 1; ATP-AMP transphosphorylase 1; ATP:AMP phosphotransferase; Adenylate monophosphate kinase; Myokinase 
Gene Name
 Ak1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
37VGGPGSGKGTQCEKIubiquitination[1]
47QCEKIVQKYGYTHLSubiquitination[1]
72SGSERGKKLSAIMEKubiquitination[1]
99LRDAMLAKVDSSNGFubiquitination[1]
116DGYPREVKQGEEFEQubiquitination[1]
163DDNEETIKKRLETYYubiquitination[1]
164DNEETIKKRLETYYNubiquitination[1]
182PVISFYDKRGIVRKVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). May provide a mechanism to buffer the adenylate energy charge for sperm motility. 
Sequence Annotation
 NP_BIND 18 23 ATP (By similarity).
 NP_BIND 65 67 AMP (By similarity).
 NP_BIND 94 97 AMP (By similarity).
 REGION 38 67 NMPbind (By similarity).
 REGION 131 141 LID (By similarity).
 BINDING 39 39 AMP (By similarity).
 BINDING 44 44 AMP (By similarity).
 BINDING 101 101 AMP (By similarity).
 BINDING 132 132 ATP (By similarity).
 BINDING 138 138 AMP (By similarity).
 BINDING 149 149 AMP (By similarity).
 BINDING 177 177 ATP; via carbonyl oxygen (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).  
Keyword
 Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 194 AA 
Protein Sequence
MGCCVSSEPQ EEGGRKTGEK LKKAKIIFVV GGPGSGKGTQ CEKIVQKYGY THLSTGDLLR 60
AEVSSGSERG KKLSAIMEKG ELVPLDTVLD MLRDAMLAKV DSSNGFLIDG YPREVKQGEE 120
FEQKIGQPTL LLYVDAGAET MTQRLLKRGE TSGRVDDNEE TIKKRLETYY NATEPVISFY 180
DKRGIVRKVN AEGTVDTVFS EVCTYLDSLK 210 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0001520; C:outer dense fiber; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0036126; C:sperm flagellum; IDA:MGI.
 GO:0004017; F:adenylate kinase activity; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046034; P:ATP metabolic process; IEA:InterPro.
 GO:0007050; P:cell cycle arrest; IDA:MGI. 
Interpro
 IPR000850; Adenylate_kin.
 IPR006267; Adenylate_kin1.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00406; ADK 
SMART
  
PROSITE
 PS00113; ADENYLATE_KINASE 
PRINTS
 PR00094; ADENYLTKNASE.