CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044773
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Acetyl-CoA carboxylase 1 
Protein Synonyms/Alias
  
Gene Name
 ACACA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
42SVPLLNSKDPIDRIIubiquitination[1, 2]
55IIEFVPTKTPYDPRWubiquitination[1, 2, 3, 4]
157FKTYQAIKDFNREGLubiquitination[3]
253PEGTVEIKFRRKDLVubiquitination[3]
335ISDILDWKTSRTFFYubiquitination[1]
419SVIEENIKCISRDYVubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 472 AA 
Protein Sequence
MHNNGVTHCT VCDDFEGVFT VLHWLSYMPK SVHSSVPLLN SKDPIDRIIE FVPTKTPYDP 60
RWMLAGRPHP TQKGQWLSGF FDYGSFSEIM QPWAQTVVVG RARLGGIPVG VVAVETRTVE 120
LSIPADPANL DSEAKIIQQA GQVWFPDSAF KTYQAIKDFN REGLPLMVFA NWRGFSGGMK 180
DMYDQVLKFG AYIVDGLREC CQPVLVYIPP QAELRGGSWV VIDSSINPRH MEMYADRESR 240
GSVLEPEGTV EIKFRRKDLV KTMRRVDPVY IHLAERLGTP ELSTAERKEL ENKLKEREEF 300
LIPIYHQVAV QFADLHDTPG RMQEKGVISD ILDWKTSRTF FYWRLRRLLL EDLVKKKIHN 360
ANPELTDGQI QAMLRRWFVE VEGTVKAYVW DNNKDLAEWL EKQLTEEDGV HSVIEENIKC 420
ISRDYVLKQI RSLVQANPEV AMDSIIHMTQ HISPTQRAEV IRILSTMDSP ST 472 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0003989; F:acetyl-CoA carboxylase activity; IEA:Compara.
 GO:0006084; P:acetyl-CoA metabolic process; IEA:Compara.
 GO:0006633; P:fatty acid biosynthetic process; IEA:Compara.
 GO:0055088; P:lipid homeostasis; IEA:Compara.
 GO:0044268; P:multicellular organismal protein metabolic process; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0001894; P:tissue homeostasis; IEA:Compara. 
Interpro
 IPR000022; Carboxyl_trans.
 IPR011763; COA_CT_C. 
Pfam
 PF01039; Carboxyl_trans 
SMART
  
PROSITE
 PS50989; COA_CT_CTER 
PRINTS