CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000361
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Period circadian protein homolog 2 
Protein Synonyms/Alias
 hPER2; Circadian clock protein PERIOD 2 
Gene Name
 PER2 
Gene Synonyms/Alias
 KIAA0347 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
384LMLAIHKKILQSGGQubiquitination[1, 2, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation (By similarity). 
Sequence Annotation
 DOMAIN 181 248 PAS 1.
 DOMAIN 321 387 PAS 2.
 DOMAIN 395 438 PAC.
 REGION 557 771 CSNK1E binding domain (By similarity).
 REGION 1155 1255 CRY binding domain (By similarity).
 MOTIF 459 471 Nuclear export signal (By similarity).
 MOTIF 789 805 Nuclear localization signal (By
 MOD_RES 527 527 Phosphoserine (By similarity).
 MOD_RES 530 530 Phosphoserine (By similarity).
 MOD_RES 533 533 Phosphoserine (By similarity).
 MOD_RES 540 540 Phosphoserine (By similarity).
 MOD_RES 662 662 Phosphoserine.
 MOD_RES 696 696 Phosphoserine (By similarity).
 MOD_RES 700 700 Phosphoserine (By similarity).
 MOD_RES 714 714 Phosphoserine (By similarity).
 MOD_RES 766 766 Phosphoserine (By similarity).
 MOD_RES 771 771 Phosphoserine (By similarity).
 MOD_RES 945 945 Phosphoserine (By similarity).
 MOD_RES 977 977 Phosphoserine (By similarity).
 MOD_RES 1124 1124 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Biological rhythms; Complete proteome; Cytoplasm; Disease mutation; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1255 AA 
Protein Sequence
MNGYAEFPPS PSNPTKEPVE PQPSQVPLQE DVDMSSGSSG HETNENCSTG RDSQGSDCDD 60
SGKELGMLVE PPDARQSPDT FSLMMAKSEH NPSTSGCSSD QSSKVDTHKE LIKTLKELKV 120
HLPADKKAKG KASTLATLKY ALRSVKQVKA NEEYYQLLMS SEGHPCGADV PSYTVEEMES 180
VTSEHIVKNA DMFAVAVSLV SGKILYISDQ VASIFHCKRD AFSDAKFVEF LAPHDVGVFH 240
SFTSPYKLPL WSMCSGADSF TQECMEEKSF FCRVSVRKSH ENEIRYHPFR MTPYLVKVRD 300
QQGAESQLCC LLLAERVHSG YEAPRIPPEK RIFTTTHTPN CLFQDVDERA VPLLGYLPQD 360
LIETPVLVQL HPSDRPLMLA IHKKILQSGG QPFDYSPIRF RARNGEYITL DTSWSSFINP 420
WSRKISFIIG RHKVRVGPLN EDVFAAHPCT EEKALHPSIQ ELTEQIHRLL LQPVPHSGSS 480
GYGSLGSNGS HEHLMSQTSS SDSNGHEDSR RRRAEICKNG NKTKNRSHYS HESGEQKKKS 540
VTEMQTNPPA EKKAVPAMEK DSLGVSFPEE LACKNQPTCS YQQISCLDSV IRYLESCNEA 600
ATLKRKCEFP ANVPALRSSD KRKATVSPGP HAGEAEPPSR VNSRTGVGTH LTSLALPGKA 660
ESVASLTSQC SYSSTIVHVG DKKPQPELEM VEDAASGPES LDCLAGPALA CGLSQEKEPF 720
KKLGLTKEVL AAHTQKEEQS FLQKFKEIRK LSIFQSHCHY YLQERSKGQP SERTAPGLRN 780
TSGIDSPWKK TGKNRKLKSK RVKPRDSSES TGSGGPVSAR PPLVGLNATA WSPSDTSQSS 840
CPAVPFPAPV PAAYSLPVFP APGTVAAPPA PPHASFTVPA VPVDLQHQFA VQPPPFPAPL 900
APVMAFMLPS YSFPSGTPNL PQAFFPSQPQ FPSHPTLTSE MASASQPEFP SRTSIPRQPC 960
ACPATRATPP SAMGRASPPL FQSRSSSPLQ LNLLQLEEAP EGGTGAMGTT GATETAAVGA 1020
DCKPGTSRDQ QPKAPLTRDE PSDTQNSDAL STSSGLLNLL LNEDLCSASG SAASESLGSG 1080
SLGCDASPSG AGSSDTSHTS KYFGSIDSSE NNHKAKMNTG MEESEHFIKC VLQDPIWLLM 1140
ADADSSVMMT YQLPSRNLEA VLKEDREKLK LLQKLQPRFT ESQKQELREV HQWMQTGGLP 1200
AAIDVAECVY CENKEKGNIC IPYEEDIPSL GLSEVSDTKE DENGSPLNHR IEEQT 1255 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000988; F:protein binding transcription factor activity; ISS:BHF-UCL.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0007623; P:circadian rhythm; TAS:ProtInc.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001610; PAC.
 IPR000014; PAS.
 IPR013655; PAS_fold_3.
 IPR022728; Period_circadian-like_C. 
Pfam
 PF08447; PAS_3
 PF12114; Period_C 
SMART
 SM00086; PAC
 SM00091; PAS 
PROSITE
 PS50113; PAC
 PS50112; PAS 
PRINTS