UniProt Accession

 XPP1_MOUSE; Q6P1B1; Q91Y37 

Genbank Protein ID

 AF363970; BC065174 

Genbank Nucleotide ID

 AAK48945.1; AAH65174.1 

Protein Name

 Xaa-Pro aminopeptidase 1 

Protein Synonyms/Alias

 Aminoacylproline aminopeptidase; Cytosolic aminopeptidase P; Soluble aminopeptidase P; sAmp; X-Pro aminopeptidase 1; X-prolyl aminopeptidase 1, soluble 

Gene Name

 Xpnpep1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
130	IIPTDYWKKMAKVLR	acetylation	[1, 2, 3]
130	IIPTDYWKKMAKVLR	succinylation	[3]
269	RIQVLPYKSILSELK	acetylation	[4]
287	ADLSPREKVWVSDKA	acetylation	[2, 3]
304	AVSEAIPKDHRCCMP	acetylation	[2]
441	GTPTAYEKECFTYVL	acetylation	[4]
441	GTPTAYEKECFTYVL	ubiquitination	[5]
546	VVLVVPAKTKYNFNN	ubiquitination	[5]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (By similarity). 

Sequence Annotation

 METAL 415 415 Manganese 1 (By similarity).
 METAL 426 426 Manganese 1 (By similarity).
 METAL 426 426 Manganese 2 (By similarity).
 METAL 489 489 Manganese 2 (By similarity).
 METAL 523 523 Manganese 1 (By similarity).
 METAL 523 523 Manganese 2 (By similarity).
 METAL 537 537 Manganese 1 (By similarity).
 METAL 537 537 Manganese 2 (By similarity).
 MOD_RES 304 304 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Aminopeptidase; Complete proteome; Cytoplasm; Hydrolase; Manganese; Metal-binding; Metalloprotease; Protease; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 623 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0030145; F:manganese ion binding; ISS:UniProtKB.
 GO:0070006; F:metalloaminopeptidase activity; ISS:UniProtKB.
 GO:0010815; P:bradykinin catabolic process; ISS:UniProtKB.
 GO:0006508; P:proteolysis; ISS:UniProtKB. 

Interpro

 IPR000587; Creatinase.
 IPR000994; Pept_M24_structural-domain.
 IPR001131; Peptidase_M24B_aminopep-P_CS. 

Pfam

 PF01321; Creatinase_N
 PF00557; Peptidase_M24 

SMART

  

PROSITE

 PS00491; PROLINE_PEPTIDASE 

PRINTS