UniProt Accession

 NRIP1_MOUSE; Q8CBD1; Q3U166; Q8C3Y8; Q9Z2K2 

Genbank Protein ID

 AF053062; AK036273; AK084498; AK156233; BC060232 

Genbank Nucleotide ID

 AAC69611.1; BAC29368.1; BAC39197.1; BAE33634.1; AAH60232.1 

Protein Name

 Nuclear receptor-interacting protein 1 

Protein Synonyms/Alias

 Nuclear factor RIP140; Receptor-interacting protein 140 

Gene Name

 Nrip1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
111	SIVNLNVKKEALLAG	acetylation	[1]
158	QQIRQSLKEQGYALS	acetylation	[1, 2]
287	YSREHALKTQNAHQV	acetylation	[1, 2]
311	RLQENGQKDVGSSQL	acetylation	[1]
482	KIPGVDIKEDQDTST	acetylation	[1]
529	DIHSDGTKFSPQNYT	acetylation	[1]
607	LMDLTKGKESQAEKP	acetylation	[1]
932	RSWARESKSFNVLKQ	acetylation	[1]

Reference

 [1] Post-translational modification of nuclear co-repressor receptor-interacting protein 140 by acetylation.
 Huq MD, Wei LN.
 Mol Cell Proteomics. 2005 Jul;4(7):975-83. [PMID: 15879431]
 [2] Modulation of lysine acetylation-stimulated repressive activity by Erk2-mediated phosphorylation of RIP140 in adipocyte differentiation.
 Ho PC, Gupta P, Tsui YC, Ha SG, Huq M, Wei LN.
 Cell Signal. 2008 Oct;20(10):1911-9. [PMID: 18655826] 

Functional Description

 Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. 

Sequence Annotation

 REGION 1 416 Interaction with ZNF366 (By similarity).
 REGION 78 335 Repression domain 1 (By similarity).
 REGION 411 701 Repression domain 2 (By similarity).
 REGION 432 473 Required for targeting to small nuclear
 REGION 736 886 Repression domain 3 (By similarity).
 REGION 754 1161 Interaction with ZNF366 (By similarity).
 REGION 1063 1076 Ligand-dependent nuclear receptor
 REGION 1121 1161 Repression domain 4 (By similarity).
 MOTIF 21 25 LXXLL motif 1.
 MOTIF 133 137 LXXLL motif 2.
 MOTIF 185 189 LXXLL motif 3.
 MOTIF 267 271 LXXLL motif 4.
 MOTIF 382 386 LXXLL motif 5.
 MOTIF 441 447 CTBP-binding; principal site (By
 MOTIF 501 505 LXXLL motif 6.
 MOTIF 566 570 CTBP-binding (By similarity).
 MOTIF 714 718 LXXLL motif 7.
 MOTIF 820 824 LXXLL motif 8.
 MOTIF 937 941 LXXLL motif 9.
 MOTIF 947 951 CTBP-binding (By similarity).
 MOD_RES 104 104 Phosphoserine.
 MOD_RES 111 111 N6-acetyllysine.
 MOD_RES 158 158 N6-acetyllysine.
 MOD_RES 207 207 Phosphothreonine.
 MOD_RES 287 287 N6-acetyllysine.
 MOD_RES 311 311 N6-acetyllysine.
 MOD_RES 358 358 Phosphoserine.
 MOD_RES 380 380 Phosphoserine.
 MOD_RES 447 447 N6-acetyllysine (By similarity).
 MOD_RES 482 482 N6-acetyllysine.
 MOD_RES 488 488 Phosphoserine.
 MOD_RES 519 519 Phosphoserine.
 MOD_RES 529 529 N6-acetyllysine.
 MOD_RES 531 531 Phosphoserine.
 MOD_RES 543 543 Phosphoserine.
 MOD_RES 607 607 N6-acetyllysine.
 MOD_RES 672 672 Phosphoserine.
 MOD_RES 932 932 N6-acetyllysine.
 MOD_RES 1003 1003 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Receptor; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1161 AA 

Protein Sequence

Gene Ontology

 GO:0000118; C:histone deacetylase complex; IPI:UniProtKB.
 GO:0003713; F:transcription coactivator activity; IEA:Compara.
 GO:0003714; F:transcription corepressor activity; IDA:MGI.
 GO:0019915; P:lipid storage; IMP:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0001543; P:ovarian follicle rupture; IMP:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR026649; NRIP1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS