CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006130
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Delta(14)-sterol reductase 
Protein Synonyms/Alias
 C-14 sterol reductase; Sterol C14-reductase 
Gene Name
 ERG24 
Gene Synonyms/Alias
 YNL280C; N0593 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
96ILPGRVMKGVQLRDGubiquitination[1]
417DEHKCRLKYGENWEEacetylation[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Reduces the C14=C15 double bond of 4,4-dimethyl- cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24- dienol. 
Sequence Annotation
  
Keyword
 Complete proteome; Lipid biosynthesis; Lipid metabolism; Membrane; NADP; Oxidoreductase; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 438 AA 
Protein Sequence
MVSALNPRTT EFEFGGLIGA LGISIGLPVF TIILNQMIRP DYFIKGFFQN FDIVELWNGI 60
KPLRYYLGNR ELWTVYCLWY GILAVLDVIL PGRVMKGVQL RDGSKLSYKI NGIAMSTTLV 120
LVLAIRWKLT DGQLPELQYL YENHVSLCII SILFSFFLAT YCYVASFIPL IFKKNGNGKR 180
EKILALGGNS GNIIYDWFIG RELNPRLGPL DIKMFSELRP GMLLWLLINL SCLHHHYLKT 240
GKINDALVLV NFLQGFYIFD GVLNEEGVLT MMDITTDGFG FMLAFGDLSL VPFTYSLQAR 300
YLSVSPVELG WVKVVGILAI MFLGFHIFHS ANKQKSEFRQ GKLENLKSIQ TKRGTKLLCD 360
GWWAKSQHIN YFGDWLISLS WCLATWFQTP LTYYYSLYFA TLLLHRQQRD EHKCRLKYGE 420
NWEEYERKVP YKIIPYVY 438 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0050613; F:delta14-sterol reductase activity; IDA:SGD.
 GO:0006696; P:ergosterol biosynthetic process; IMP:SGD. 
Interpro
 IPR001171; Ergosterol_biosynth_ERG4_ERG24.
 IPR018083; Sterol_reductase_CS. 
Pfam
 PF01222; ERG4_ERG24 
SMART
  
PROSITE
 PS01017; STEROL_REDUCT_1
 PS01018; STEROL_REDUCT_2 
PRINTS