UniProt Accession

 TRPR_SALTY; P37444 

Genbank Protein ID

 AE006468 

Genbank Nucleotide ID

 AAL23398.1 

Protein Name

 Trp operon repressor 

Protein Synonyms/Alias

  

Gene Name

 trpR 

Gene Synonyms/Alias

 STM4583 

Created Date

 July 27, 2013 

Organism

 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 

NCBI Taxa ID

 99287 

Lysine Modification

Position	Peptide	Type	References
72	EMSQRELKTELGAGI	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity). 

Sequence Annotation

 DNA_BIND 68 91 By similarity.  

Keyword

 Complete proteome; Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 108 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:HAMAP.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000831; Trp_repress.
 IPR013335; Trp_repress_bac.
 IPR010921; Trp_repressor/repl_initiator. 

Pfam

 PF01371; Trp_repressor 

SMART

  

PROSITE

  

PRINTS