CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036423
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Catenin alpha-2 
Protein Synonyms/Alias
  
Gene Name
 Ctnna2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
28IILKWDPKSLEIRTLubiquitination[1]
57TLVNTSNKGPSGKKKubiquitination[1]
93EKGEQIAKESQDLKEubiquitination[1]
371NNTGRKEKGDPLNIAubiquitination[1]
428SGNEKEVKEYAQVFRubiquitination[1]
902ASYVASTKYQKVYGTacetylation[2]
902ASYVASTKYQKVYGTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 966 AA 
Protein Sequence
MTDIHSSYTY TGSMTSATSP IILKWDPKSL EIRTLTVERL LEPLVTQVTT LVNTSNKGPS 60
GKKKGRSKKA HVLAASVEQA TQNFLEKGEQ IAKESQDLKE ELVAAVEDVR KQGETMRIAS 120
SEFADDPCSS VKRGTMVRAA RALLSAVTRL LILADMADVM RLLSHLKIVE EALEAVKNAT 180
NEQDLANRFK EFGKEMVKLN YVAARRQQEL KDPHCRDEMA AARGALKKNA TMLYTASQAF 240
LRHPDVAATR ANRDYVFKQV QEAIAGISSA AQATSPTDEA KGHTGIGELA AALNEFDNKI 300
ILDPMTFSEA RFRPSLEERL ESIISGAALM ADSSCTRDDR RERIVAECNA VRQALQDLLS 360
EYMNNTGRKE KGDPLNIAID KMTKKTRDLR RQLRKAVMDH ISDSFLETNV PLLVLIEAAK 420
SGNEKEVKEY AQVFREHANK LVEVANLACS ISNNEEGVKL VRMAATQIDS LCPQVINAAL 480
TLAARPQSKV AQDNMDVFKD QWEKQVRVLT EAVDDITSVD DFLSVSENHI LEDVNKCVIA 540
LQEGDVDTLD RTAGAIRGRA ARVIHIINAE MENYEAGVYT EKVLEATKLL SETVMPRFAE 600
QVEVAIEALS ANVPQPFEEN EFIDASRLVY DGVRDIRKAV LMIRTPEELE DDSDFEQEDY 660
DVRSRTSVQT EDDQLIAGQS ARAIMAQLPQ EEKAKIAEQV EIFHQEKSKL DAEVAKWDDS 720
GNDIIVLAKQ MCMIMMEMTD FTRGKGPLKN TSDVINAAKK IAEAGSRMDK LARAVADQCP 780
DSACKQDLLA YLQRIALYCH QLNICSKVKA EVQNLGGELI VSGTGVQSTF TTFYEVDCDV 840
IDGGRASQLS THLPTCAEGA PIGSGSSDSS MLDSATSLIQ AAKNLMNAVV LTVKASYVAS 900
TKYQKVYGTA AVNSPVVSWK MKAPEKKPLV KREKPEEFQT RVRRGSQKKH ISPVQALSEF 960
KAMDSF 966 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IEA:InterPro.
 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0005913; C:cell-cell adherens junction; IDA:MGI.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0007155; P:cell adhesion; IEA:InterPro. 
Interpro
 IPR001033; Alpha_catenin.
 IPR006077; Vinculin/catenin.
 IPR000633; Vinculin_CS. 
Pfam
 PF01044; Vinculin 
SMART
  
PROSITE
 PS00663; VINCULIN_1 
PRINTS
 PR00805; ALPHACATENIN.