CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038389
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Myoferlin 
Protein Synonyms/Alias
  
Gene Name
 Myof 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
16ATNIPKTKFGKPDPIacetylation[1]
19IPKTKFGKPDPIVSVacetylation[2]
102QNRSLPYKQTSLLNEubiquitination[3]
313EDTSSGAKGYMKVSMacetylation[2]
540EKKPPEKKLEPISSDacetylation[1]
978INRAVDEKGWEYGITacetylation[1]
1352FMKVFLPKEELYMPPacetylation[2, 4]
1494TFKLYRGKSDENEDPacetylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2048 AA 
Protein Sequence
MLRVIVESAT NIPKTKFGKP DPIVSVIFKD EKKKTKKVDN ELNPVWNEIL EFDLRGIPLD 60
SSSSLVIVVK DFETIGQNKL IGTATVSLKD LIGDQNRSLP YKQTSLLNEK GQDTGATIDL 120
VIGYTPPSAP HPNDPSGTSV PGMGEEEEED QGDEDRVDGI VRGPGPKGPS GTVSEAQLAR 180
RITKGKSSRR MLSNKPQDFQ IRVRVIEGRQ LCGNNIRPVV KVHICGQTHR TRIKRGNNPF 240
FDELFFYNVH ITPSELMDEI ISIRVYNSHS LRADCLMGEF KIDVGFVYDE PGHAVMRKWL 300
LLNDPEDTSS GAKGYMKVSM FVLGTGDEPP PEKRDRDNDS DDVESNLLLP AGIALRWVTF 360
MLKIYRAEDI PQMDDAFSQT VKEIFGGNAD KKNLVDPFVE VSFAGKKVCT NIIERNANPE 420
WNQVVNLQIK FPSMCEKIKL TVYDWDRLTK NDVVGTTYLY LSKIAASGGE VEATTGETEV 480
GFVPTFGPCY LNLYGSPREY TGFPDPYDEL NSGKGEGVAY RGRIFVELNT FLEKKPPEKK 540
LEPISSDDLL VVEKYQRRRK YSLSAVFHSA TMLQDVGEAI QFEVSIGNYG NKFDATCKPL 600
ASTTQYSRAV FDGNYYYYLP WAHTKPVVTL TSYWEDISHR LDAVNTLLVM AERLQSNIEA 660
VKSGIQGKIP ANQLAEVWLK LIDEVIEDTR YTLPVTEGKA NVTVLDTQIR KLRSRFLSQI 720
HEAALRMRSE ATDVKSTLLE IEEWLDKLMQ LTEEPQNSMP DIIIWMIRGE KRLAYARIPA 780
HQVLYSTSGG NASGKYCGKT QTILLKYPQE KTNGPKVPVE LRVNIWLGLS AVEKKFNSFA 840
EGTFTVFAEM YENQALVFGK WGTSGLVGRH KFSDVTGKIK LKREFFLPPK GWEWEGDWVV 900
DPERSLLTEA DAGHTEFTDE VYQNENRYPG GEWKQAEDTY TDANGDKAAS PSEMTCPPGW 960
EWEDDAWIYD INRAVDEKGW EYGITIPPDN KPKSWVAAEK MYHTHRRRRL VRKRKKDLTQ 1020
TASSTARAME ELEDREGWEY ASLIGWKFHW KQRSSDTFRR RRWRRKMAPS ETHGAAAIFK 1080
LEGALGADTT EDGEEKGPEK QKHSATTVFG ANTPIVSCNF DRVYIYHLRC YIYQARNLMA 1140
LDKDSFSDPY AHVSFLHRSK TTEIIHSTLN PTWDQTIIFD EVEIFGEPQT VLQNPPNVTI 1200
ELFDNDQVGK DEFLGRSICS PLVKLNSETD ITPKLLWHPV MNGDKACGDV LVTAELILRN 1260
KDGSNLPILP SQRAPNLYMV PQGIRPVVQL TAIEILAWGL RNMKNYQMAS VTSPSLVVEC 1320
GGERVESVVI KSLKKTPNFP SSVLFMKVFL PKEELYMPPL VIKVIDHRQF GRKPVVGQCT 1380
IDHLDRFRCD PYAGKEDIVP QLKASLMSAP PCREVVIEIE DTKPLLASKM SKQLEEIVDW 1440
WSKFYASSGE HEKCGQYIQK GYSKLKIYDC ELEDVADFEG LTDFSDTFKL YRGKSDENED 1500
PSVVGEFKGS FRIYPLPDDP SVPAPPRQFR ELPDSVPQEC TVRIYIVQGL QLQPQDNNGL 1560
CDPYIKITLG KKVIEDRDHY IPNTLNPVFG RMYELSCYLP QEKDLKISVY DYDTFTRDEK 1620
VGETTIDLEN RFLSRFGSHC GIPEQYCVSG VNTWRDQLRP TQLLQNVARF KGFPPPVLSE 1680
DGSRIRYGGR DYHLDEFEAN KILHQHLGAP EERLALHILR TQGLVPEHVE TRTLHSTFQP 1740
NISQGKLQMW VDVFPKSLGP PGPPFNITPR KAKKYYLRVI IWNTKDVILD EKSITGEDMS 1800
DIYVKGWISG SEENKQKTDV HYRSLDGEGN FNWRFVFPFD YLPAEQLCIV AKKEHFWSID 1860
QTEFRVPPRL IIQIWDNDKF SLDDYLGFLE LDLHRTIIPA KTSEKCSLDM IPDLKAMDPL 1920
KAKTASLFEQ RSMKGWWPCY ADKDGTRVMA GKVEMTLEVL NEREADERPA GKGRSEPNMN 1980
PKLDPPNRPE TSFLWFTNPC KTMRFIVWRR FKWVIIGLLL LLILLLFVAV LLYSLPNYLS 2040
MKIVRPNA 2048 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0034605; P:cellular response to heat; IDA:MGI. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR012968; FerIin-domain.
 IPR012560; Ferlin_A-domain.
 IPR012561; Ferlin_B-domain.
 IPR006614; Peroxin/Ferlin. 
Pfam
 PF00168; C2
 PF08165; FerA
 PF08150; FerB
 PF08151; FerI 
SMART
 SM00239; C2
 SM00694; DysFC
 SM00693; DysFN 
PROSITE
 PS50004; C2 
PRINTS