CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035530
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Plch1 
Protein Synonyms/Alias
  
Gene Name
 Plch1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
207LKQNLDVKESGKKSHacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Complete proteome; Reference proteome; Transducer. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1336 AA 
Protein Sequence
MYARVLQEGC RCVEVDCWDG PDGEPVVHHG YTLTSKILFK DVVETINKHA FVKNEFPVIL 60
SIENHCSIQQ QRKIAQYLKG IFQDKLDLSS VDTGECRQLP SPQSLKGKIL VKGKKLPYHL 120
GDDAEEGEVS DEDSADEIED ECKFKLHYSN GTTEHQVESF IRKKLDSLLK ESQIRDKEDP 180
DSFTVRALLK ATHEGLNAHL KQNLDVKESG KKSHGRSLMA NFGKHKKTPK SRSKSYSTDD 240
EEDTLQNPGK EGGQLYRLGR RRRTMKLCRE LSDLVVYTNS VAAQDIVDDG TTGNVLSFSE 300
TRAHQVVQQK SEQFMIYNQK QLTRIYPSAY RIDSSNFNPL PYWNAGCQLV ALNYQSEGRM 360
MQINRAKFKA NGNCGYILKP QQMCKGTFNP LSGDPLPANP KKQLILKVIS GQQLPKPPDS 420
MFGDRGEIID PFVEVEIIGL PVDCCKDQTR VVDDNGFNPV WEETLTFTVH MPEIALVRFL 480
VWDHDPIGRD FVGQRTVTFS SLVPGYRHVY LEGLTEASIF VHITINEIFG KNRQLQGLKG 540
LFNKNPRHGS SENNSHYVRK RSIGDRILRR TASAPAKGRK KSKVGFQEMV EIKDSVCEAT 600
RDQDGVLRRT TRSLQLRPVS MPVDKNLLGA LSLPISEAAK NTDGKENYLA EDKDDGRKGP 660
ATIKDPHFSN FNKKLSSSSS ALLHKDAKNQ GPTASVSNPE QCGGLGLKSG RIKPHMTNDC 720
QENRSPQNFL SPRKHLALDP ATKGLQDLHG MRTDEKEQER AKGFVGRKST QSESVLSQSS 780
LEVENLEGSK AKGRAATSFS LSDVSALCSD IPDLHSTAIL QDTEISDLIN DVTLTNANES 840
GSSISALIGQ FEESNHRANV AVVSRLLSTS GTSEGVALPV ALGLQTPIKN GFSQGKHKAS 900
FLCSSPELNK PSSAETTKLA NNTVACGVIG SPISTPKPGD DASDKAKTRV TEDNLPDSPD 960
AFPGQFPQSP THGEDHRQVM SSPALSMPLA MEDTTADPAL CINSEESSLV EIDGDSESLS 1020
LTACDYGEEA LSQLVSPLKL QQSQETVEHI QKGLSNGYCK ETLLPSEIFN NIPGVKNQSI 1080
SHLTYQGAGF VYNHFSSSDA KTNQICGPQQ PRAPDMHVPT PTPSTHAPLA ALKLPSPCKS 1140
KSLGDLTSED IACNFESKYQ CISRSFVTNS IRDKSVTMKT KSFEPLDALT EQLRKLVSFD 1200
QEDSCQGLYS KQDVNQCPRA LVRKLSSRSQ SRVRNIASRA KEKQEAGKQK AMTQNPRGGV 1260
VLRSKPPAPT LAVNRHSTGS YIASYLRNMK ASGLEGRGIP EGACTALRYG YRSNGPVLQT 1320
EPSSEDKPEI YFLLRL 1336 
Gene Ontology
 GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0006629; P:lipid metabolic process; IEA:InterPro. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR001192; Pinositol_PLipase_C.
 IPR017946; PLC-like_Pdiesterase_TIM-brl.
 IPR000909; PLipase_C_PInositol-sp_X_dom.
 IPR001711; PLipase_C_Pinositol-sp_Y. 
Pfam
 PF00168; C2
 PF00388; PI-PLC-X
 PF00387; PI-PLC-Y 
SMART
 SM00239; C2
 SM00148; PLCXc
 SM00149; PLCYc 
PROSITE
 PS50004; C2
 PS50007; PIPLC_X_DOMAIN
 PS50008; PIPLC_Y_DOMAIN 
PRINTS
 PR00390; PHPHLIPASEC.