UniProt Accession

 RCD1_HUMAN; Q92600; B2RPI0; Q96IX4 

Genbank Protein ID

 D87957; CH471063; BC007102; BC137455; BC137456 

Genbank Nucleotide ID

 BAA13508.1; EAW70625.1; AAH07102.2; AAI37456.1; AAI37457.1 

Protein Name

 Cell differentiation protein RCD1 homolog 

Protein Synonyms/Alias

 Rcd-1; CCR4-NOT transcription complex subunit 9 

Gene Name

 RQCD1 

Gene Synonyms/Alias

 CNOT9; RCD1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
44	NALLELSKKRESVPD	ubiquitination	[1]
45	ALLELSKKRESVPDL	ubiquitination	[1]
222	KMVLQLSKEPSARLL	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 3D-structure; Acetylation; Activator; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Polymorphism; Reference proteome; Repressor; RNA-mediated gene silencing; Transcription; Transcription regulation; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 299 AA 

Protein Sequence

Gene Ontology

 GO:0030014; C:CCR4-NOT complex; IDA:UniProtKB.
 GO:0000932; C:cytoplasmic mRNA processing body; ISS:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0019221; P:cytokine-mediated signaling pathway; IEA:Compara.
 GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
 GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; IMP:UniProtKB.
 GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; TAS:Reactome.
 GO:2000327; P:positive regulation of ligand-dependent nuclear receptor transcription coactivator activity; IDA:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
 GO:0007548; P:sex differentiation; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR007216; Rcd1. 

Pfam

 PF04078; Rcd1 

SMART

  

PROSITE

  

PRINTS