CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033293
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Myoferlin 
Protein Synonyms/Alias
  
Gene Name
 MYOF 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
102QSRSLPYKLISLLNEubiquitination[1, 2, 3, 4]
167AVRGPGPKGPVGTVSubiquitination[2]
406VEVSFAGKKVCTNIIubiquitination[4]
527YDELNTGKGEGVAYRubiquitination[2, 4]
547ELATFLEKTPPDKKLubiquitination[4]
567DDLLVVEKYQRRRKYubiquitination[4]
712TLPLTEGKANVTVLDubiquitination[4]
947RYPGGDWKPAEDTYTubiquitination[4]
1109TTEDGDEKSLEKQKHubiquitination[2, 3, 4]
1223FDNDQVGKDEFLGRSubiquitination[2, 4]
1237SIFSPVVKLNSEMDIubiquitination[2, 4]
1247SEMDITPKLLWHPVMubiquitination[4]
1274AELILRGKDGSNLPIubiquitination[4]
1344RVESVVIKNLKKTPNubiquitination[4]
1416EDIVPQLKASLLSAPubiquitination[4]
1436VIEMEDTKPLLASKCubiquitination[4]
1475EIVDWWSKFYASSGEubiquitination[4]
1485ASSGEHEKCGQYIQKubiquitination[3]
1526TFKLYRGKSDENEDPubiquitination[2, 4]
1540PSVVGEFKGSFRIYPubiquitination[4]
1652DTFTRDEKVGETIIDubiquitination[4]
1703LQNVARFKGFPQPILubiquitination[4]
1788RVIIWNTKDVILDEKubiquitination[4]
1795KDVILDEKSITGEEMubiquitination[2, 3, 4]
1808EMSDIYVKGWIPGNEubiquitination[2, 4]
1908IPAKSPEKCRLDMIPubiquitination[4]
1918LDMIPDLKAMNPLKAubiquitination[2, 3, 4]
1924LKAMNPLKAKTASLFubiquitination[4]
1934TASLFEQKSMKGWWPubiquitination[4]
2004LWFTNPCKTMKFIVWubiquitination[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2051 AA 
Protein Sequence
MLRVIVESAS NIPKTKFGKP DPIVSVIFKD EKKKTKKVDN ELNPVWNEIL EFDLRGIPLD 60
FSSSLGIIVK DFETIGQNKL IGTATVALKD LTGDQSRSLP YKLISLLNEK GQDTGATIDL 120
VIGYDPPSAP HPNDLSGPSV PGMGGDGEED EGDEDRLDNA VRGPGPKGPV GTVSEAQLAR 180
RLTKVKNSRR MLSNKPQDFQ IRVRVIEGRQ LSGNNIRPVV KVHVCGQTHR TRIKRGNNPF 240
FDELFFYNVN MTPSELMDEI ISIRVYNSHS LRADCLMGEF KIDVGFVYDE PGHAVMRKWL 300
LLNDPEDTSS GSKGYMKVSM FVLGTGDEPP PERRDRDNDS DDVESNLLLP AGIALRWVTF 360
LLKIYRAEDI PQMDDAFSQT VKEIFGGNAD KKNLVDPFVE VSFAGKKVCT NIIEKNANPE 420
WNQVVNLQIK FPSVCEKIKL TIYDWDRLTK NDVVGTTYLH LSKIAASGGE VEDFSSSGTG 480
AASYTVNTGE TEVGFVPTFG PCYLNLYGSP REYTGFPDPY DELNTGKGEG VAYRGRILVE 540
LATFLEKTPP DKKLEPISND DLLVVEKYQR RRKYSLSAVF HSATMLQDVG EAIQFEVSIG 600
NYGNKFDTTC KPLASTTQYS RAVFDGNYYY YLPWAHTKPV VTLTSYWEDI SHRLDAVNTL 660
LAMAERLQTN IEALKSGIQG KIPANQLAEL WLKLIDEVIE DTRYTLPLTE GKANVTVLDT 720
QIRKLRSRSL SQIHEAAVRM RSEATDVKST LAEIEDWLDK LMQLTEEPQN SMPDIIIWMI 780
RGEKRLAYAR IPAHQVLYST SGENASGKYC GKTQTIFLKY PQEKNNGPKV PVELRVNIWL 840
GLSAVEKKFN SFAEGTFTVF AEMYENQALM FGKWGTSGLV GRHKFSDVTG KIKLKREFFL 900
PPKGWEWEGE WIVDPERSLL TEADAGHTEF TDEVYQNESR YPGGDWKPAE DTYTDANGDK 960
AASPSELTCP PGWEWEDDAW SYDINRAVDE KGWEYGITIP PDHKPKSWVA AEKMYHTHRR 1020
RRLVRKRKKD LTQTASSTAR AMEELQDQEG WEYASLIGWK FHWKQRSSDT FRRRRWRRKM 1080
APSETHGAAA IFKLEGALGA DTTEDGDEKS LEKQKHSATT VFGANTPIVS CNFDRVYIYH 1140
LRCYVYQARN LLALDKDSFS DPYAHICFLH RSKTTEIIHS TLNPTWDQTI IFDEVEIYGE 1200
PQTVLQNPPK VIMELFDNDQ VGKDEFLGRS IFSPVVKLNS EMDITPKLLW HPVMNGDKAC 1260
GDVLVTAELI LRGKDGSNLP ILPPQRAPNL YMVPQGIRPV VQLTAIEILA WGLRNMKNFQ 1320
MASITSPSLV VECGGERVES VVIKNLKKTP NFPSSVLFMK VFLPKEELYM PPLVIKVIDH 1380
RQFGRKPVVG QCTIERLDRF RCDPYAGKED IVPQLKASLL SAPPCRDIVI EMEDTKPLLA 1440
SKCLSSMSTA LSKMASPATV HVLDEEEEIV DWWSKFYASS GEHEKCGQYI QKGYSKLKIY 1500
NCELENVAEF EGLTDFSDTF KLYRGKSDEN EDPSVVGEFK GSFRIYPLPD DPSVPAPPRQ 1560
FRELPDSVPQ ECTVRIYIVR GLELQPQDNN GLCDPYIKIT LGKKVIEDRD HYIPNTLNPV 1620
FGRMYELSCY LPQEKDLKIS VYDYDTFTRD EKVGETIIDL ENRFLSRFGS HCGIPEEYCV 1680
SGVNTWRDQL RPTQLLQNVA RFKGFPQPIL SEDGSRIRYG GRDYSLDEFE ANKILHQHLG 1740
APEERLALHI LRTQGLVPEH VETRTLHSTF QPNISQRYYL RVIIWNTKDV ILDEKSITGE 1800
EMSDIYVKGW IPGNEENKQK TDVHYRSLDG EGNFNWRFVF PFDYLPAEQL CIVAKKEHFW 1860
SIDQTEFRIP PRLIIQIWDN DKFSLDDYLG FLELDLRHTI IPAKSPEKCR LDMIPDLKAM 1920
NPLKAKTASL FEQKSMKGWW PCYAEKDGAR VMAGKVEMTL EILNEKEADE RPAGKGRDEP 1980
NMNPKLDLPN RPETSFLWFT NPCKTMKFIV WRRFKWVIIG LLFLLILLLF VAVLLYSLPN 2040
YLSMKIVKPN V 2051 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR012968; FerIin-domain.
 IPR012560; Ferlin_A-domain.
 IPR012561; Ferlin_B-domain.
 IPR006614; Peroxin/Ferlin. 
Pfam
 PF00168; C2
 PF08165; FerA
 PF08150; FerB
 PF08151; FerI 
SMART
 SM00239; C2
 SM00694; DysFC
 SM00693; DysFN 
PROSITE
 PS50004; C2 
PRINTS