UniProt Accession

 PKHO2_HUMAN; Q8TD55; Q7L4H4; Q8WYS8 

Genbank Protein ID

 AF494534; AC069368; CH471082; CH471082; BC008744; AF318373 

Genbank Nucleotide ID

 AAM18053.1; EAW77697.1; EAW77699.1; AAH08744.2; AAL55880.1 

Protein Name

 Pleckstrin homology domain-containing family O member 2 

Protein Synonyms/Alias

 PH domain-containing family O member 2; Pleckstrin homology domain-containing family Q member 1; PH domain-containing family Q member 1 

Gene Name

 PLEKHO2 

Gene Synonyms/Alias

 PLEKHQ1; PP9099 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
37	GGLLGFWKDRYLLLC	ubiquitination	[1, 2, 3, 4, 5]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

 DOMAIN 18 119 PH.
 MOD_RES 232 232 Phosphothreonine (By similarity).
 MOD_RES 235 235 Phosphoserine (By similarity).
 MOD_RES 278 278 Phosphoserine (By similarity).
 MOD_RES 390 390 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 490 AA 

Protein Sequence

Gene Ontology

 GO:0005543; F:phospholipid binding; IEA:InterPro. 

Interpro

 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 

Pfam

 PF00169; PH 

SMART

 SM00233; PH 

PROSITE

 PS50003; PH_DOMAIN 

PRINTS