CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016575
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Copine-3 
Protein Synonyms/Alias
 Copine III 
Gene Name
 Cpne3 
Gene Synonyms/Alias
 Kiaa0636 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
76FEVVQKLKFGIYDIDacetylation[1]
158DNKDLFGKSDPYLEFubiquitination[2]
167DPYLEFHKQTSDGHWacetylation[1]
167DPYLEFHKQTSDGHWubiquitination[2]
253EYECINEKKRQKKKSacetylation[3]
253EYECINEKKRQKKKSubiquitination[2]
262RQKKKSYKNSGVISVubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity). 
Sequence Annotation
 DOMAIN 2 99 C2 1.
 DOMAIN 125 230 C2 2.
 DOMAIN 291 513 VWFA.
 MOD_RES 242 242 Phosphoserine.  
Keyword
 Complete proteome; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 533 AA 
Protein Sequence
MAAQCVTKVE LNVSCNNLLD ADVTSKSDPL CVLFLNTSGH QWYEVERTER IKNSLNPKFS 60
KTFVIDYYFE VVQKLKFGIY DIDNKTIELS DDDFLGECEV TLGQIVSSKK LTRPLVLKNG 120
KPAGKGSITI SAEEIKDNRV VLFEMEARKL DNKDLFGKSD PYLEFHKQTS DGHWLMVHRT 180
EVIKNNLNPM WKPFKISLNS LCYGDMDKTI KVECYDYDND GSHDLIGTFQ TTMTKLKEAS 240
RSSPVEYECI NEKKRQKKKS YKNSGVISVK HCEITVECTF LDYIMGGCQL NFTVGVDFTG 300
SNGDPSSPDS LHYISPNGVN EYLTAIWSVG LVIQDYDADK MFPAFGFGAQ VPPQWQVSHE 360
FPMNFNPSNP YCNGIQGIVE AYRTCLPQIR LYGPTNFSPI INHVARFAAA ATQQQTASQY 420
FVLLIITDGV ITDLDETRQA IVNAAKLPMS IIIVGVGGAD FSAMEFLDGD GGSLRAPSGE 480
VAIRDIVQFV PFRQFQNAPK EALAQCVLAE IPQQVVGYFN TYKLLPPKNP AVK 533 
Gene Ontology
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR010734; Copine.
 IPR002035; VWF_A. 
Pfam
 PF00168; C2
 PF07002; Copine 
SMART
 SM00239; C2
 SM00327; VWA 
PROSITE
 PS50004; C2
 PS50234; VWFA 
PRINTS